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Clin Nutr

Title:		"Galacto-oligosaccharides supplementation in prefrail older and healthy adults increased faecal bifidobacteria, but did not impact immune function and oxidative stress"
Author(s):		Wilms E; An R; Smolinska A; Stevens Y; Weseler AR; Elizalde M; Drittij MJ; Ioannou A; van Schooten FJ; Smidt H; Masclee AAM; Zoetendal EG; Jonkers D;
Address:		"Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands. Electronic address: ellen.wilms@mumc.nl. Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands. Department of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands. Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands"
Journal Title:		Clin Nutr
Year:		2021
Volume:		20210112
Issue:		5
Page Number:		3019 - 3031
DOI:		10.1016/j.clnu.2020.12.034
ISSN/ISBN:		1532-1983 (Electronic) 0261-5614 (Linking)
Abstract:		"BACKGROUND & AIMS: Ageing is associated with an increased risk of frailty, intestinal microbiota perturbations, immunosenescence and oxidative stress. Prebiotics such as galacto-oligosaccharides (GOS) may ameliorate these ageing-related alterations. We aimed to compare the faecal microbiota composition, metabolite production, immune and oxidative stress markers in prefrail elderly and younger adults, and investigate the effects of GOS supplementation in both groups. METHODS: In a randomised controlled cross-over study, 20 prefrail elderly and 24 healthy adults received 21.6 g/day Biotis GOS (containing 15.0 g/day GOS) or placebo. Faecal 16S rRNA gene-based microbiota and short-chain fatty acids were analysed at 0, 1 and 4 weeks of intervention.Volatile organic compounds were analysed in breath, and stimulated cytokine production, CRP, malondialdehyde, trolox equivalent antioxidant capacity (TEAC) and uric acid (UA) in blood at 0 and 4 weeks. RESULTS: Principle coordinate analysis showed differences in microbial composition between elderly and adults (P/= 0.125) nor were affected by GOS (P >/= 0.236). TEAC values corrected for UA were higher in elderly versus adults (P<0.001), but not different between interventions (P >/= 0.455). CONCLUSIONS: Elderly showed lower faecal bifidobacterial (relative) abundance than adults, which increased after GOS intake in both groups. Faecal and breath metabolites, parameters of immune function and oxidative stress were not different at baseline, and not impacted by GOS supplementation. CLINICALTRIALS. GOV WITH STUDY ID NUMBER: NCT03077529"
Keywords:		"Adult Age Factors Aged Aged, 80 and over Bifidobacterium/*isolation & purification Cross-Over Studies *Dietary Supplements Feces/*microbiology Female Galactose/*pharmacology Humans Immunity/*drug effects Male Middle Aged Oligosaccharides/*pharmacology Oxi;"
Notes:		"MedlineWilms, Ellen An, Ran Smolinska, Agnieszka Stevens, Yala Weseler, Antje R Elizalde, Montserrat Drittij, Marie-Jose Ioannou, Athanasia van Schooten, Frederik J Smidt, Hauke Masclee, Ad A M Zoetendal, Erwin G Jonkers, Daisy M A E eng Randomized Controlled Trial Research Support, Non-U.S. Gov't England 2021/01/30 Clin Nutr. 2021 May; 40(5):3019-3031. doi: 10.1016/j.clnu.2020.12.034. Epub 2021 Jan 12"