| Title: | Comprehensive analysis between volatile organic compound (VOC) exposure and female sex hormones: a cross-sectional study from NHANES 2013-2016 |
| Author(s): | Wei C; Pan Y; Zhang W; He Q; Chen Z; Zhang Y; |
| Address: | "Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. The First Clinical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. Department of Nephrology, Clinical Research Center of Kidney Disease in Sichuan Province, Sichuan Provincial People's Hospital, Medicine of School, University of Electronic Science and Technology of China, Chengdu, 611731, China. zhangyuansz@med.uestc.edu.cn" |
| Journal Title: | Environ Sci Pollut Res Int |
| DOI: | 10.1007/s11356-023-29125-0 |
| ISSN/ISBN: | 1614-7499 (Electronic) 0944-1344 (Linking) |
| Abstract: | "There is growing evidence suggesting that exposure to volatile organic compounds (VOCs) can pose significant health risks, including interference with the function of the reproductive system. However, there has been a lack of research focused on the impact of common environmental VOCs on the levels of sex hormones in the general female population. In this study, we conducted a cross-sectional analysis utilizing the database of the National Health and Nutrition Examination Survey (NHANES, 2013-2016). A total of 2633 participants were included in this study. The Pearson correlation model revealed the potential of co-exposure or co-toxicity between benzene and 2,5-dimethylfuran. According to GLM models, we discovered a significant positive association between blood levels of 2,5-dimethylfuran and benzene with testosterone levels in women. Subgroup analysis further identified that the women with underweight and healthy weight might be the high-risk subgroup. Bayesian kernel machine regression (BKMR) was applied to further assess the univariate and bivariate exposure-response relationships between multiple VOCs. Our research systemically formulated the possible relationship between exposure to VOCs and female sex hormones, indicating the role of VOCs as a risk factor for endocrine disruption, especially benzene and 2,5-dimethylfuran. These findings have important implications for public health and call for further investigation" |
| Keywords: | "Humans Female *Volatile Organic Compounds/analysis Cross-Sectional Studies Environmental Exposure/analysis Nutrition Surveys Benzene/analysis *Air Pollutants/analysis Bayes Theorem Gonadal Steroid Hormones/analysis 2, 5-Dimethylfuran Benzene Estradiol (E2);" |
| Notes: | "MedlineWei, Chengcheng Pan, Yao Zhang, Wenting He, Qingliu Chen, Zhaohui Zhang, Yuan eng Germany 2023/08/10 Environ Sci Pollut Res Int. 2023 Sep; 30(42):95828-95839. doi: 10.1007/s11356-023-29125-0. Epub 2023 Aug 10" |
