| Title: | "Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001-2010" |
| Author(s): | Wei C; Chen Y; Yang Y; Ni D; Huang Y; Wang M; Yang X; Chen Z; |
| Address: | "Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Urology, Ezhou Central Hospital, Ezhou, China. Department of Pathologist and Laboratory Medicine, Staff Pathologist, Deaconess Hospital, Evansville, IN, United States" |
| DOI: | 10.3389/fpubh.2022.957069 |
| ISSN/ISBN: | 2296-2565 (Electronic) 2296-2565 (Linking) |
| Abstract: | "BACKGROUND: Volatile organic compounds (VOCs) are a large group of chemicals widely used in people's daily routines. Increasing evidence revealed the VOCs' accumulating toxicity. However, the VOCs toxicity in male prostate has not been reported previously. Thus, we comprehensively evaluated the association between VOCs and prostate-specific antigen (PSA). METHODS: A total of 2016 subjects were included in our study from the National Health and Nutrition Examination Survey with VOCs, PSA, and other variables among U.S. average population. We constructed XGBoost Algorithm Model, Regression Model, and Generalized linear Model (GAM) to analyze the potential association. Stratified analysis was used to identify high-risk populations. RESULTS: XGBoost Algorithm model identified blood chloroform as the most critical variable in the PSA concentration. Regression analysis suggested that blood chloroform was a positive association with PSA, which showed that environmental chloroform exposure is an independent risk factor that may cause prostate gland changes [beta, (95% CI), P = 0.007, (0.003, 0.011), 0.00019]. GAM observed the linear relationship between blood chloroform and PSA concentration. Meanwhile, blood chloroform linear correlated with water chloroform in the lower dose range, indicating that the absorption of water may be the primary origin of chloroform. Stratified associations analysis identified the high-risk group on the chloroform exposures. CONCLUSION: This study revealed that blood chloroform was positively and independently associated with total PSA level, suggesting that long-term environmental chloroform exposure may cause changes in the prostate gland" |
| Keywords: | Chloroform/analysis Humans Male Nutrition Surveys *Prostate-Specific Antigen *Volatile Organic Compounds/analysis Water National Health and Nutrition Examination Survey (NHANES) chloroform prostate-specific antigen (PSA) public health volatile organic com; |
| Notes: | "MedlineWei, Chengcheng Chen, Yumao Yang, Yu Ni, Dong Huang, Yu Wang, Miao Yang, Xiong Chen, Zhaohui eng Switzerland 2022/08/16 Front Public Health. 2022 Jul 29; 10:957069. doi: 10.3389/fpubh.2022.957069. eCollection 2022" |
