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PLoS One

Title:		Clinical contributions of exhaled volatile organic compounds in the diagnosis of lung cancer
Author(s):		Oguma T; Nagaoka T; Kurahashi M; Kobayashi N; Yamamori S; Tsuji C; Takiguchi H; Niimi K; Tomomatsu H; Tomomatsu K; Hayama N; Aoki T; Urano T; Magatani K; Takeda S; Abe T; Asano K;
Address:		"Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. Ogino Memorial Laboratory, Nihon Kohden Corporation, Tokyo, Japan. Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan. Department of Electrical and Electronic Engineering, Tokai University School of Engineering, Kanagawa, Japan"
Journal Title:		PLoS One
Year:		2017
Volume:		20170406
Issue:		4
Page Number:		e0174802 -
DOI:		10.1371/journal.pone.0174802
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"BACKGROUND: Exhaled volatile organic compounds (VOC) are being considered as biomarkers for various lungs diseases, including cancer. However, the accurate measurement of extremely low concentrations of VOC in expired air is technically challenging. We evaluated the clinical contribution of exhaled VOC measured with a new, double cold-trap method in the diagnosis of lung cancer. METHODS: Breath samples were collected from 116 patients with histologically confirmed lung cancer and 37 healthy volunteers (controls) after inspiration of purified air, synthesized through a cold-trap system. The exhaled VOC, trapped in the same system, were heat extracted. We analyzed 14 VOC with gas chromatography. RESULTS: The concentrations of exhaled cyclohexane and xylene were significantly higher in patients with lung cancer than in controls (p = 0.002 and 0.0001, respectively), increased significantly with the progression of the clinical stage of cancer (both p < 0.001), and decreased significantly after successful treatment of 6 patients with small cell lung cancer (p = 0.06 and 0.03, respectively). CONCLUSION: Measurements of exhaled VOCs by a double cold-trap method may help diagnose lung cancer and monitor its progression and regression"
Keywords:		Adult Breath Tests/*methods Case-Control Studies Female Gas Chromatography-Mass Spectrometry Humans Limit of Detection Lung Neoplasms/*diagnosis Male Middle Aged Volatile Organic Compounds/*analysis Young Adult;
Notes:		"MedlineOguma, Tsuyoshi Nagaoka, Takashi Kurahashi, Muneshige Kobayashi, Naofumi Yamamori, Shinji Tsuji, Chizuko Takiguchi, Hiroto Niimi, Kyoko Tomomatsu, Hiromi Tomomatsu, Katsuyoshi Hayama, Naoki Aoki, Takuya Urano, Tetsuya Magatani, Kazushige Takeda, Sunao Abe, Tadashi Asano, Koichiro eng 2017/04/07 PLoS One. 2017 Apr 6; 12(4):e0174802. doi: 10.1371/journal.pone.0174802. eCollection 2017"