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PLoS One

Title:		"Microbial inhibitors of the fungus Pseudogymnoascus destructans, the causal agent of white-nose syndrome in bats"
Author(s):		Micalizzi EW; Mack JN; White GP; Avis TJ; Smith ML;
Address:		"Department of Biology, Carleton University, Ottawa, Ontario, Canada. RIFDS Inc., Ottawa, Ontario, Canada. Department of Chemistry, Carleton University, Ottawa, Ontario, Canada"
Journal Title:		PLoS One
Year:		2017
Volume:		20170620
Issue:		6
Page Number:		e0179770 -
DOI:		10.1371/journal.pone.0179770
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"Pseudogymnoascus destructans, the fungus that causes white-nose syndrome in hibernating bats, has spread across eastern North America over the past decade and decimated bat populations. The saprotrophic growth of P. destructans may help to perpetuate the white-nose syndrome epidemic, and recent model predictions suggest that sufficiently reducing the environmental growth of P. destructans could help mitigate or prevent white-nose syndrome-associated bat colony collapse. In this study, we screened 301 microbes from diverse environmental samples for their ability to inhibit the growth of P. destructans. We identified 145 antagonistic isolates, 53 of which completely or nearly completely inhibited the growth of P. destructans in co-culture. Further analysis of our best antagonists indicated that these microbes have different modes of action and may have some specificity in inhibiting P. destructans. The results suggest that naturally-occurring microbes and/or their metabolites may be considered further as candidates to ameliorate bat colony collapse due to P. destructans"
Keywords:		Animals *Antibiosis Ascomycota/drug effects/*growth & development Bacillus/growth & development/metabolism Chiroptera/*microbiology Gas Chromatography-Mass Spectrometry Mycoses/*microbiology/pathology/prevention & control Pantoea/growth & development/meta;
Notes:		"MedlineMicalizzi, Emma W Mack, Jonathan N White, George P Avis, Tyler J Smith, Myron L eng 2017/06/21 PLoS One. 2017 Jun 20; 12(6):e0179770. doi: 10.1371/journal.pone.0179770. eCollection 2017"