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Int J Hyg Environ Health

Title:		Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017
Author(s):		Lee I; Park H; Kim MJ; Kim S; Choi S; Park J; Cho YH; Hong S; Yoo J; Cheon GJ; Choi K; Park YJ; Moon MK;
Address:		"School of Public Health, Seoul National University, Seoul, South Korea. Department of Laboratory Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea. School of Public Health, Seoul National University, Seoul, South Korea; Chemical Safety Research Center, Korea Research Institute of Chemical Technology, Daejeon, South Korea. College of Natural Science, Soonchunhyang University, Asan, South Korea. Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA. Environmental Health Research Division, National Institute of Environmental Research, Ministry of Environment, Incheon, South Korea. Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Devision of Endocrinology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea. Electronic address: mkmoon@snu.ac.kr"
Journal Title:		Int J Hyg Environ Health
Year:		2022
Volume:		20211202
Issue:
Page Number:		113886 -
DOI:		10.1016/j.ijheh.2021.113886
ISSN/ISBN:		1618-131X (Electronic) 1438-4639 (Linking)
Abstract:		"Environmental pollutants have been known to increase the risks of not only respiratory and cardiovascular disease but also metabolic diseases such as obesity and diabetes mellitus (DM). Polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) such as benzene and toluene are major constituents of environmental pollution. In the present study, we employed the population of the Korean National Environmental Health Survey (KoNEHS) Cycle 3 conducted between 2015 and 2017, and assessed the associations of urinary biomarkers for PAHs and VOCs exposure with obesity and DM. A total of 3787 adult participants were included and the urinary concentrations of four PAH metabolites and two VOC metabolites were measured. For correcting urine dilution, a covariate-adjusted standardization method was used. The highest quartiles of urinary 2-hydroxynaphthalene (2-NAP) [OR (95% confidence interval (CI)) = 1.46 (1.13, 1.87)] and sum of PAH metabolites [OR (95% CI) = 1.45 (1.13, 1.87)] concentrations were associated with a higher risk of obesity [body mass index (BMI)>/=25 kg/m(2)]. BMI was positively associated with urinary 2-NAP [beta (95% CI) = 0.25 (0.09, 0.41), p = 0.003] and sum of PAH metabolites [beta (95% CI) = 0.29 (0.08, 0.49), p = 0.006] concentrations. The risk of DM was increased with increasing quartile of 2-hydroxyfluorene (2-OHFlu) and trans, trans-muconic acid (t,t-MA) (p for trend<0.05 and < 0.001, respectively). The highest quartile of t,t-MA showed a significantly higher risk of DM [OR (95% CI) = 2.77 (1.74, 4.42)] and obesity [OR (95% CI) = 1.42 (1.06, 1.90)]. Urinary t,t,-MA level was positively associated with BMI [(beta (95% CI) = 0.51 (0.31, 0.71), p < 0.001] and non-alcoholic fatty liver disease index [(beta (95% CI) = 0.09 (0.06, 0.12), p < 0.001]. In conclusion, the benzene metabolites t,t-MA and PAH metabolite 2-OHFlu were associated with an increased risk of DM. Urinary biomarkers for PAHs and VOCs were positively associated with BMI in the Korean adult population. Further studies to validate these observations in other populations are warranted"
Keywords:		Adult Biomarkers/urine *Diabetes Mellitus/chemically induced/epidemiology Environmental Exposure/analysis Environmental Health Humans Obesity/epidemiology *Polycyclic Aromatic Hydrocarbons/urine Republic of Korea/epidemiology *Volatile Organic Compounds D;
Notes:		"MedlineLee, Inae Park, Hyunwoong Kim, Min Joo Kim, Sunmi Choi, Sohyeon Park, Jeongim Cho, Yoon Hee Hong, Sooyeon Yoo, Jiyoung Cheon, Gi Jeong Choi, Kyungho Park, Young Joo Moon, Min Kyong eng Research Support, Non-U.S. Gov't Germany 2021/12/06 Int J Hyg Environ Health. 2022 Mar; 240:113886. doi: 10.1016/j.ijheh.2021.113886. Epub 2021 Dec 2"