| Title: | Differentiation of complex vapor mixtures using versatile DNA-carbon nanotube chemical sensor arrays |
| Author(s): | Kybert NJ; Lerner MB; Yodh JS; Preti G; Johnson AT; |
| Address: | "Department of Physics and Astronomy and Nano/Bio Interface Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States" |
| ISSN/ISBN: | 1936-086X (Electronic) 1936-0851 (Linking) |
| Abstract: | "Vapor sensors based on functionalized carbon nanotubes (NTs) have shown great promise, with high sensitivity conferred by the reduced dimensionality and exceptional electronic properties of the NT. Critical challenges in the development of NT-based sensor arrays for chemical detection include the demonstration of reproducible fabrication methods and functionalization schemes that provide high chemical diversity to the resulting sensors. Here, we outline a scalable approach to fabricating arrays of vapor sensors consisting of NT field effect transistors functionalized with single-stranded DNA (DNA-NT). DNA-NT sensors were highly reproducible, with responses that could be described through equilibrium thermodynamics. Target analytes were detected even in large backgrounds of volatile interferents. DNA-NT sensors were able to discriminate between highly similar molecules, including structural isomers and enantiomers. The sensors were also able to detect subtle variations in complex vapors, including mixtures of structural isomers and mixtures of many volatile organic compounds characteristic of humans" |
| Keywords: | "*Biosensing Techniques Cyclohexenes/analysis/chemistry *DNA, Single-Stranded/chemistry Hemiterpenes Humans Limonene Nanotechnology Nanotubes, Carbon/*chemistry Pentanoic Acids/analysis Static Electricity Stereoisomerism Terpenes/analysis/chemistry Thermod;" |
| Notes: | "MedlineKybert, Nicholas J Lerner, Mitchell B Yodh, Jeremy S Preti, George Johnson, A T Charlie eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2013/02/28 ACS Nano. 2013 Mar 26; 7(3):2800-7. doi: 10.1021/nn400359c. Epub 2013 Mar 5" |
