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Ecotoxicol Environ Saf

Title:		Exposure to volatile organic compounds may be associated with oxidative DNA damage-mediated childhood asthma
Author(s):		Kuang H; Li Z; Lv X; Wu P; Tan J; Wu Q; Li Y; Jiang W; Pang Q; Wang Y; Fan R;
Address:		"Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School o f Life Sciences, South China Normal University, Guangzhou 510631, China. Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou 510631, China. Guangzhou Women and Children's Medical Center, Guangzhou 510120, China. Guangzhou Quality Supervision and Testing Institute, Guangzhou 511447, China. Department of Mathematical Science, South China Normal University, Guangzhou 510631, China. Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School o f Life Sciences, South China Normal University, Guangzhou 510631, China. Electronic address: 20001047@m.scnu.edu.cn"
Journal Title:		Ecotoxicol Environ Saf
Year:		2021
Volume:		20210104
Issue:
Page Number:		111864 -
DOI:		10.1016/j.ecoenv.2020.111864
ISSN/ISBN:		1090-2414 (Electronic) 0147-6513 (Linking)
Abstract:		"Volatile organic compounds (VOCs) are important and ubiquitous air pollutants, which may lead to a significant increase in the prevalence of respiratory diseases. To investigate the relationships between VOCs exposure and childhood asthma, 252 asthmatic children and 69 healthy children were recruited. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG, a biomarker of oxidative DNA damage), trans-3'-hydroxycotinine (OH-Cot, a biomarker of passive smoking) and 27 VOC metabolites were simultaneously determined by an ultra-high-performance liquid chromatography-tandem mass spectrometer. Results showed that levels of 8-OHdG and most VOC metabolites in asthmatic children were significantly higher than those in healthy children. More than half of the VOC metabolites were significantly and positively associated with OH-Cot with maximal beta coefficient of 0.169, suggesting that second-hand smoking is one important source of VOCs exposure for children in Guangzhou. Significant dose-response relationships between most VOC metabolites and 8-OHdG were observed. Each unit increase in ln-transformed VOC metabolite levels was significantly associated with 5.5-32% increase in ln-transformed 8-OHdG level. Moreover, each unit increase in ln-transformed 8-OHdG level was associated with an 896% increased odd ratios (OR) of asthma in children (OR = 9.96, 95% confidence intervals (CI): 4.75, 20.9), indicating that oxidative stress induced by VOCs exposure may have a significant impact on childhood asthma. Urinary 3-&4-Methylhippuric acid (3-&4-MHA, OR: 5.78, 95% CI: 3.50, 9.54), rac 2-Aminothiazoline-4-carboxylic acid (ATCA, OR: 2.90, 95% CI: 1.69, 4.99) and N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA, OR: 2.76, 95% CI: 1.73, 4.43) which may derive from m/p-xylene, cyanide and 1,3-butadiene exposure, respectively, could significantly and maximally increase the odds of asthma. Interestingly, they also had the strongest associations with 8-OHdG among all investigated VOC metabolites. Moreover, DHBMA strongly correlated with most VOC metabolites. Hence, DHBMA is a suitable biomarker to indicate not only VOCs exposure profile, but also the DNA damage-mediated asthma induced by VOCs"
Keywords:		8-Hydroxy-2'-Deoxyguanosine/urine Asthma/epidemiology/*urine Biological Monitoring Biomarkers/urine Child China/epidemiology Cotinine/analogs & derivatives/urine Environmental Pollutants/metabolism/*urine Female Humans Male *Oxidative Stress Tobacco Smoke;
Notes:		"MedlineKuang, Hongxuan Li, Zhilin Lv, Xuejing Wu, Peiqiong Tan, Jianhua Wu, Qiurong Li, Yonghong Jiang, Wenhui Pang, Qihua Wang, Yaru Fan, Ruifang eng Netherlands 2021/01/08 Ecotoxicol Environ Saf. 2021 Mar 1; 210:111864. doi: 10.1016/j.ecoenv.2020.111864. Epub 2021 Jan 4"