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Cell

Title:		Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation
Author(s):		Jefferis GS; Potter CJ; Chan AM; Marin EC; Rohlfing T; Maurer CR; Luo L;
Address:		"Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA. gsxej2@cam.ac.uk"
Journal Title:		Cell
Year:		2007
Volume:		128
Issue:		6
Page Number:		1187 - 1203
DOI:		10.1016/j.cell.2007.01.040
ISSN/ISBN:		0092-8674 (Print) 1097-4172 (Electronic) 0092-8674 (Linking)
Abstract:		"In Drosophila, approximately 50 classes of olfactory receptor neurons (ORNs) send axons to 50 corresponding glomeruli in the antennal lobe. Uniglomerular projection neurons (PNs) relay olfactory information to the mushroom body (MB) and lateral horn (LH). Here, we combine single-cell labeling and image registration to create high-resolution, quantitative maps of the MB and LH for 35 input PN channels and several groups of LH neurons. We find (1) PN inputs to the MB are stereotyped as previously shown for the LH; (2) PN partners of ORNs from different sensillar groups are clustered in the LH; (3) fruit odors are represented mostly in the posterior-dorsal LH, whereas candidate pheromone-responsive PNs project to the anterior-ventral LH; (4) dendrites of single LH neurons each overlap with specific subsets of PN axons. Our results suggest that the LH is organized according to biological values of olfactory input"
Keywords:		Animals Brain/anatomy & histology/physiology Brain Mapping Drosophila/*anatomy & histology/*physiology Female Fruit Male Mushroom Bodies/*physiology Odorants Olfactory Pathways/physiology Olfactory Receptor Neurons/*physiology Pheromones Presynaptic Termi;
Notes:		"MedlineJefferis, Gregory S X E Potter, Christopher J Chan, Alexander M Marin, Elizabeth C Rohlfing, Torsten Maurer, Calvin R Jr Luo, Liqun eng R01 AA005965/AA/NIAAA NIH HHS/ U01 AA013521/AA/NIAAA NIH HHS/ R37 AA005965/AA/NIAAA NIH HHS/ R01-DC005982/DC/NIDCD NIH HHS/ R01 DC005982/DC/NIDCD NIH HHS/ AA05965/AA/NIAAA NIH HHS/ AA13521/AA/NIAAA NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2007/03/27 Cell. 2007 Mar 23; 128(6):1187-203. doi: 10.1016/j.cell.2007.01.040"