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Biochimie

Title:		[Control of the cell division cycle and sporulation in Saccharomyces cerevisiae by the cyclic AMP system]
Author(s):		Jacquet M; Camonis J;
Address:
Journal Title:		Biochimie
Year:		1985
Volume:		67
Issue:		1
Page Number:		35 - 43
DOI:		10.1016/s0300-9084(85)80228-5
ISSN/ISBN:		0300-9084 (Print) 0300-9084 (Linking)
Abstract:		"This paper reviews recent data on the adenylate cyclase system of the yeast Saccharomyces cerevisiae. Since the discovery of yeast adenylate cyclase mutants and the possibility of molecular biological analysis, adenylate cyclase and the subsequent steps in the cAMP cascade have become subject of intense investigation. CYR1, the structural gene for the adenylate cyclase catalytic subunit is necessary for cell division and in diploid cells is involved in the choice between sporulation and cell division. The cell division cycle in yeast is initiated by a step called START, which has been defined by mutations causing an arrest of the cells in an unbudded state. One class of mutation causes the cell to arrest at the same stage of the cell division cycle as the pheromone implicated in conjugation. A second class causes cells to cease growth in a different manner, but one which is similar to the arrest brought about by nutient deprivation. The adenylate cyclase gene belongs to the second class and has been identified as CDC35. Two genes of the first class have been cloned and sequenced. CDC28 codes for a kinase which has homology with the src proto-oncogene family. CDC36 is partly homologous with the oncogene ets. Two genes related to the ras oncogene family have also been implicated in the control of START. START can be dissociated in two subsequent phases, the first being controlled by the AMPc system and the second including proto-oncogenes. A model in which cAMP is a positive indicator of available nutrients such as nitrogen has been constructed.(ABSTRACT TRUNCATED AT 250 WORDS)"
Keywords:		"Adenylyl Cyclases/*genetics Animals Base Sequence Cell Division Cloning, Molecular Cyclic AMP/*physiology Genes *Genes, Fungal Guanosine Triphosphate/pharmacology Mutation Oncogenes Phenotype Pheromones/pharmacology Protein Kinases/genetics Saccharomyces;"
Notes:		"MedlineJacquet, M Camonis, J fre Research Support, Non-U.S. Gov't Review France 1985/01/01 Biochimie. 1985 Jan; 67(1):35-43. doi: 10.1016/s0300-9084(85)80228-5"