| Title: | Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii |
| Author(s): | Yamanaka HR; Cheung C; Mendoza JS; Oliva DJ; Elzey-Aberilla K; Perrault KA; |
| Address: | "Laboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USA" |
| DOI: | 10.3390/molecules26123726 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Fast diagnostic results using breath analysis are an anticipated possibility for disease diagnosis or general health screenings. Tests that do not require sending specimens to medical laboratories possess capabilities to speed patient diagnosis and protect both patient and healthcare staff from unnecessary prolonged exposure. The objective of this work was to develop testing procedures on an initial healthy subject cohort in Hawaii to act as a range-finding pilot study for characterizing the baseline of exhaled breath prior to further research. Using comprehensive two-dimensional gas chromatography (GCxGC), this study analyzed exhaled breath from a healthy adult population in Hawaii to profile the range of different volatile organic compounds (VOCs) and survey Hawaii-specific differences. The most consistently reported compounds in the breath profile of individuals were acetic acid, dimethoxymethane, benzoic acid methyl ester, and n-hexane. In comparison to other breathprinting studies, the list of compounds discovered was representative of control cohorts. This must be considered when implementing proposed breath diagnostics in new locations with increased interpersonal variation due to diversity. Further studies on larger numbers of subjects over longer periods of time will provide additional foundational data on baseline breath VOC profiles of control populations for comparison to disease-positive cohorts" |
| Keywords: | Adolescent Adult Breath Tests/methods Exhalation/*physiology Female Gas Chromatography-Mass Spectrometry/methods Hawaii Healthy Volunteers Humans Male Middle Aged Pilot Projects Volatile Organic Compounds/*chemistry Young Adult Oahu residents breath profi; |
| Notes: | "MedlineYamanaka, Hunter R Cheung, Cynthia Mendoza, Jireh S Oliva, Danson J Elzey-Aberilla, Kealina Perrault, Katelynn A eng 17ADVC-86184/Hawaii Community Foundation/ 1752607/National Science Foundation/ Switzerland 2021/07/03 Molecules. 2021 Jun 18; 26(12):3726. doi: 10.3390/molecules26123726" |
