« Previous AbstractOxidative DNA damage estimated by urinary 8-hydroxydeoxyguanosine and indoor air pollution among non-smoking office employees    Next Abstract"Sex pheromone components in oral secretions and crop of male Caribbean fruit flies, Anastrepha suspensa (Loew)" »

Inhal Toxicol

Title:		Oxidative stress associated with indoor air pollution and sick building syndrome-related symptoms among office workers in Taiwan
Author(s):		Lu CY; Ma YC; Lin JM; Li CY; Lin RS; Sung FC;
Address:		"College of Public Health, Institute of Environmental Health, National Taiwan University, Taipei"
Journal Title:		Inhal Toxicol
Year:		2007
Volume:		19
Issue:		1
Page Number:		57 - 65
DOI:		10.1080/08958370600985859
ISSN/ISBN:		1091-7691 (Electronic) 0895-8378 (Linking)
Abstract:		"This study investigated whether sick building syndrome (SBS) complaints and indoor air pollution for office workers are associated with oxidative stress indicated by urinary 8-hydroxydeoxyguanosine (8-OHdG). With informed consent, 389 employees in 87 government offices of 8 high-rise buildings in Taipei city completed self-reported questionnaires on SBS complaints at work in the past month. Urinary 8-OHdG was determined for each study participant and on-site air pollutants were measured for each office in both indoor and outdoor air. The results showed that urinary 8-OHdG had significant associations with volatile organic compounds and carbon dioxide levels in offices, and with urinary cotinine levels. The mean urinary 8-OHdG level was also significantly higher in participants with SBS symptoms than in those without such complaints (6.16 vs. 5.45 mug/g creatinine, p = .047). The mean 8-OHdG increased as the number of SBS symptoms increased. The multivariate logistic regression analyses showed that the adjusted odds ratios (OR) in relation to micrograms per gram creatinine increase in 8-OHdG were statistically significant for eye dryness (1.12), upper respiratory syndrome (1.17) with particularly nose itching (1.25), sneezing (1.51), dry throat (1.21), skin dryness (1.31), and dizziness (1.19). This study indicates that the 8-OHdG level was significantly associated with SBS complaints after controlling for air pollution and smoking. Whether the 8-OHdG can be used as an effective predictor for SBS symptoms deserves further study"
Keywords:		"8-Hydroxy-2'-Deoxyguanosine Adult Air Pollutants, Occupational/*adverse effects *Air Pollution, Indoor Biomarkers/urine Carbon Dioxide/adverse effects Cotinine/urine Creatinine/urine Deoxyguanosine/analogs & derivatives/urine Female Humans Logistic Models;"
Notes:		"MedlineLu, Chung-Yen Ma, Yee-Chung Lin, Jia-Min Li, Chung-Yi Lin, Reuy S Sung, Fung-Chang eng Research Support, Non-U.S. Gov't England 2006/11/28 Inhal Toxicol. 2007 Jan; 19(1):57-65. doi: 10.1080/08958370600985859"