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Arch Bronconeumol

Title:		Study of 5 Volatile Organic Compounds in Exhaled Breath in Chronic Obstructive Pulmonary Disease
Author(s):		Jareno-Esteban JJ; Munoz-Lucas MA; Gomez-Martin O; Utrilla-Trigo S; Gutierrez-Ortega C; Aguilar-Ros A; Collado-Yurrita L; Callol-Sanchez LM;
Address:		"Servicio de Neumologia, Hospital Central de la Defensa, Universidad de Alcala de Henares; IMIDEF, Alcala de Henares, Madrid, Espana. Instituto Mixto de Investigacion Biosanitaria de la Defensa (IMIDEF), Hospital Central de la Defensa, Madrid, Espana. Electronic address: mmunozlucas@yahoo.es. Instituto Mixto de Investigacion Biosanitaria de la Defensa (IMIDEF), Madrid, Espana. Universidad Complutense de Madrid, Madrid, Espana. Unidad de Apoyo a la Investigacion, Hospital Central de la Defensa, Madrid, Espana. Dpto. CC Farmaceuticas, Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Espana. Dpto. de Medicina, Universidad Complutense de Madrid, Madrid, Espana. Dpto. de Medicina, Facultad de Medicina, Universidad de Alcala, Instituto Mixto de Investigacion Biosanitaria de la Defensa (IMIDEF), Alcala de Henares, Madrid, Espana"
Journal Title:		Arch Bronconeumol
Year:		2017
Volume:		20161022
Issue:		5
Page Number:		251 - 256
DOI:		10.1016/j.arbres.2016.09.003
ISSN/ISBN:		1579-2129 (Electronic) 0300-2896 (Linking)
Abstract:		"INTRODUCTION: A major risk factor for chronic obstructive pulmonary disease (COPD) is tobacco smoke, which generates oxidative stress in airways, resulting in the production of volatile organic compounds (VOC). The purpose of this study was to identify VOCs in exhaled breath and to determine their possible use as disease biomarkers. METHOD: Exhaled breath from 100 healthy volunteers, divided into 3groups (never smokers, former smokers and active smokers) and exhaled breath from 57 COPD patients were analyzed. Samples were collected using BioVOC((R)) devices and transferred to universal desorption tubes. Compounds were analyzed by thermal desorption, gas chromatography and mass spectrometry. VOCs analyzed were linear aldehydesand carboxylic acids. RESULTS: The COPD group and healthy controls (never smokers and former smokers) showed statistically significant differences in hexanal concentrations, and never smokers and the COPD group showed statistically significant differences in nonanal concentrations. CONCLUSIONS: Hexanal discriminates between COPD patients and healthy non-smoking controls. Nonanal discriminates between smokers and former smokers (with and without COPD) and never smokers"
Keywords:		"Adult Aged Aldehydes/analysis Biomarkers *Breath Tests Case-Control Studies Fatty Acids/analysis Female Humans Male Middle Aged Propionates/analysis Pulmonary Disease, Chronic Obstructive/*metabolism Smoking/metabolism Smoking Cessation Volatile Organic C;"
Notes:		"MedlineJareno-Esteban, Jose Javier Munoz-Lucas, M Angeles Gomez-Martin, Oscar Utrilla-Trigo, Sergio Gutierrez-Ortega, Carlos Aguilar-Ros, Antonio Collado-Yurrita, Luis Callol-Sanchez, Luis Miguel eng spa Spain 2016/10/27 Arch Bronconeumol. 2017 May; 53(5):251-256. doi: 10.1016/j.arbres.2016.09.003. Epub 2016 Oct 22"