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Anal Bioanal Chem

Title:		Detection of volatile organic compounds (VOCs) from exhaled breath as noninvasive methods for cancer diagnosis
Author(s):		Sun X; Shao K; Wang T;
Address:		"Institute of New Energy, State Key Laboratory of Heavy Oil Processing, China University of Petroleum (Beijing), Beijing, 102249, China. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, 100190, China. Department of Thoracic Surgery, Cancer Hospital & Institute, CAMS & PUMC, Beijing, 100021, China. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, 100190, China. wangtie@iccas.ac.cn"
Journal Title:		Anal Bioanal Chem
Year:		2016
Volume:		20151216
Issue:		11
Page Number:		2759 - 2780
DOI:		10.1007/s00216-015-9200-6
ISSN/ISBN:		1618-2650 (Electronic) 1618-2642 (Linking)
Abstract:		"The detection of cancer at an early stage is often significant in the successful treatment of the disease. Tumor cells have been reported to generate unique cancer volatile organic compound (VOC) profiles which can reflect the disease conditions. The detection and analysis of VOC biomarkers from exhaled breath has been recognized as a new frontier in cancer diagnostics and health inspections owing to its potential in developing rapid, noninvasive, and inexpensive cancer screening tools. To detect specific VOCs of low concentrations from exhaled breath, and to enhance the accuracy of early diagnosis, many breath collection and analysis approaches have been developed. This paper will summarize and critically review the exhaled-breath VOC-related sampling, collection, detection, and analytical methods, especially the recent development in VOC sensors. VOC sensors are commonly inexpensive, portable, programmable, easy to use, and can obtain data in real time with high sensitivities. Therefore, many sensor-based VOC detection techniques have huge potential in clinical point-of-care use"
Keywords:		*Breath Tests Humans Neoplasms/*diagnosis Volatile Organic Compounds/*analysis Cancer diagnosis Exhaled breath Sensors Volatile organic compounds;
Notes:		"MedlineSun, Xiaohua Shao, Kang Wang, Tie eng Research Support, Non-U.S. Gov't Review Germany 2015/12/18 Anal Bioanal Chem. 2016 Apr; 408(11):2759-80. doi: 10.1007/s00216-015-9200-6. Epub 2015 Dec 16"