| Title: | Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae |
| Author(s): | Rego A; Duarte AM; Azevedo F; Sousa MJ; Corte-Real M; Chaves SR; |
| Address: | "Centro de Biologia Molecular e Ambiental, Departamento de Biologia, Universidade do Minho, Braga, Portugal" |
| ISSN/ISBN: | 2311-2638 (Print) 2311-2638 (Electronic) 2311-2638 (Linking) |
| Abstract: | "Acetic acid triggers apoptotic cell death in Saccharomyces cerevisiae, similar to mammalian apoptosis. To uncover novel regulators of this process, we analyzed whether impairing MAPK signaling affected acetic acid-induced apoptosis and found the mating-pheromone response and, especially, the cell wall integrity pathways were the major mediators, especially the latter, which we characterized further. Screening downstream effectors of this pathway, namely targets of the transcription factor Rlm1p, highlighted decreased cell wall remodeling as particularly important for acetic acid resistance. Modulation of cell surface dynamics therefore emerges as a powerful strategy to increase acetic acid resistance, with potential application in industrial fermentations using yeast, and in biomedicine to exploit the higher sensitivity of colorectal carcinoma cells to apoptosis induced by acetate produced by intestinal propionibacteria" |
| Keywords: | Cwi Mapk acetic acid apoptosis yeast; |
| Notes: | "PubMed-not-MEDLINERego, Antonio Duarte, Ana M Azevedo, Flavio Sousa, Maria J Corte-Real, Manuela Chaves, Susana R eng Austria 2014/08/27 Microb Cell. 2014 Aug 27; 1(9):303-314. doi: 10.15698/mic2014.09.164" |
