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J Biol Phys

Title:		Disentangling signaling gradients generated by equivalent sources
Author(s):		Rappaport N; Barkai N;
Address:		"Departments of Molecular Genetics and Physics of Complex Systems, Weizmann Institute of Science, Rehovot, 76100 Israel"
Journal Title:		J Biol Phys
Year:		2012
Volume:		20110914
Issue:		2
Page Number:		267 - 278
DOI:		10.1007/s10867-011-9240-x
ISSN/ISBN:		0092-0606 (Print) 1573-0689 (Electronic) 0092-0606 (Linking)
Abstract:		"Yeast cells approach a mating partner by polarizing along a gradient of mating pheromones that are secreted by cells of the opposite mating type. The Bar1 protease is secreted by a-cells and, paradoxically, degrades the alpha-factor pheromones which are produced by cells of the opposite mating type and trigger mating in a-cells. This degradation may assist in the recovery from pheromone signaling but has also been shown to play a positive role in mating. Previous studies suggested that widely diffusing protease can bias the pheromone gradient towards the closest secreting cell. Here, we show that restricting the Bar1 protease to the secreting cell itself, preventing its wide diffusion, facilitates discrimination between equivalent mating partners. This may be mostly relevant during spore germination, where most mating events occur in nature"
Keywords:		Gradient Mating Yeast;
Notes:		"PubMed-not-MEDLINERappaport, Noa Barkai, Naama eng P50 GM068763/GM/NIGMS NIH HHS/ Netherlands 2013/03/02 J Biol Phys. 2012 Mar; 38(2):267-78. doi: 10.1007/s10867-011-9240-x. Epub 2011 Sep 14"