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Diagnostics (Basel)

Title:		Identification of Key Volatile Organic Compounds Released by Gastric Tissues as Potential Non-Invasive Biomarkers for Gastric Cancer
Author(s):		Mochalski P; Leja M; Slefarska-Wolak D; Mezmale L; Patsko V; Ager C; Krolicka A; Mayhew CA; Shani G; Haick H;
Address:		"Institute of Chemistry, Jan Kochanowski University of Kielce, PL-25406 Kielce, Poland. Institute for Breath Research, University of Innsbruck, A-6850 Dornbirn, Austria. Institute of Clinical and Preventive Medicine, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia. Digestive Diseases Centre GASTRO, LV-1586 Riga, Latvia. Riga East University Hospital, LV-1586 Riga, Latvia. National Cancer Institute of Ukraine, 03022 Kyiv, Ukraine. Department of Building Materials Technology, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, PL-30059 Krakow, Poland. Department of Chemical Engineering, Russel Berrie Nanotechnology Institute, Technicon-Israel Institute of Technology, Haifa 3200003, Israel"
Journal Title:		Diagnostics (Basel)
Year:		2023
Volume:		20230117
Issue:		3
Page Number:		-
DOI:		10.3390/diagnostics13030335
ISSN/ISBN:		2075-4418 (Print) 2075-4418 (Electronic) 2075-4418 (Linking)
Abstract:		"BACKGROUND: Volatilomics is a powerful tool capable of providing novel biomarkers for medical diagnosis and therapy monitoring. The objective of this study is to identify potential volatile biomarkers of gastric cancer. METHODS: The volatilomic signatures of gastric tissues obtained from two distinct populations were investigated using gas chromatography with mass spectrometric detection. RESULTS: Amongst the volatiles emitted, nineteen showed differences in their headspace concentrations above the normal and cancer tissues in at least one population of patients. Headspace levels of seven compounds (hexanal, nonanal, cyclohexanone, 2-nonanone, pyrrole, pyridine, and phenol) were significantly higher above the cancer tissue, whereas eleven volatiles (ethyl acetate, acetoin, 2,3-butanedione, 3-methyl-1-butanol, 2-pentanone, gamma-butyrolactone, DL-limonene, benzaldehyde, 2-methyl-1-propanol, benzonitrile, and 3-methyl-butanal) were higher above the non-cancerous tissue. One compound, isoprene, exhibited contradictory alterations in both cohorts. Five compounds, pyridine, ethyl acetate, acetoin, 2,3-butanedione, and 3-methyl-1-butanol, showed consistent cancer-related changes in both populations. CONCLUSIONS: Pyridine is found to be the most promising biomarker candidate for detecting gastric cancer. The difference in the volatilomic signatures can be explained by cancer-related changes in the activity of certain enzymes, or pathways. The results of this study confirm that the chemical fingerprint formed by volatiles in gastric tissue is altered by gastric cancer"
Keywords:		Gc-ms biomarker gastric cancer gastric tissue volatile organic compound;
Notes:		"PubMed-not-MEDLINEMochalski, Pawel Leja, Marcis Slefarska-Wolak, Daria Mezmale, Linda Patsko, Veronika Ager, Clemens Krolicka, Agnieszka Mayhew, Chris A Shani, Gidi Haick, Hossam eng 824986/European Commission/ 2021/41/N/ST4/02307/National Science Center/ 8.2.2.0/20/1/006/ESF SAM 8.2.2.3./ Switzerland 2023/02/12 Diagnostics (Basel). 2023 Jan 17; 13(3):335. doi: 10.3390/diagnostics13030335"