| Title: | Breath-based diagnosis of fungal infections |
| Author(s): | Acharige MJT; Koshy S; Ismail N; Aloum O; Jazaerly M; Astudillo CL; Koo S; |
| Address: | "Division of Infectious Diseases, Brigham and Women's Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115, United States of America. Harvard Medical School, 25 Shattuck St., Boston, MA 02115, United States of America" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Invasive aspergillosis and other invasive fungal infections are associated with significant morbidity and mortality in immunocompromised patients, in large part due to limitations of existing diagnostic methods for these infections. Detection of species-specific volatile sesquiterpene metabolites of fungal origin in the breath of patients with invasive fungal infections allows the diagnosis and monitoring of these infections in vivo, non-invasively and more rapidly than possible with current diagnostic methods. While detection of exogenous microbial volatile metabolites in the breath has opened up a new and exciting dimension of diagnostic research and development in infectious diseases, we discuss the daunting challenges to volatile diagnostic biomarker discovery and clinical development" |
| Keywords: | Aspergillosis/diagnosis Breath Tests/*methods Humans Mycoses/*diagnosis Species Specificity Volatile Organic Compounds/analysis/chemistry; |
| Notes: | "MedlineAcharige, Mahesh J Thalavitiya Koshy, Seena Ismail, Nour Aloum, Obadah Jazaerly, Majd Astudillo, Carmen Leon Koo, Sophia eng K23 AI097225/AI/NIAID NIH HHS/ Review England 2017/11/08 J Breath Res. 2018 Feb 6; 12(2):027108. doi: 10.1088/1752-7163/aa98a1" |
