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J Insect Physiol

Title:		Mutations at the Darkener of Apricot locus modulate pheromone production and sex behavior in Drosophila melanogaster
Author(s):		Fumey J; Wicker-Thomas C;
Address:		"Evolution, Genomes, Comportement & Ecologie, CNRS, IRD, Universite Paris Sud, Universite Paris-Saclay, 91198 Gif sur Yvette, France. Evolution, Genomes, Comportement & Ecologie, CNRS, IRD, Universite Paris Sud, Universite Paris-Saclay, 91198 Gif sur Yvette, France. Electronic address: Claude.Wicker-thomas@egce.cnrs-gif.fr"
Journal Title:		J Insect Physiol
Year:		2017
Volume:		20170111
Issue:
Page Number:		182 - 187
DOI:		10.1016/j.jinsphys.2017.01.005
ISSN/ISBN:		1879-1611 (Electronic) 0022-1910 (Linking)
Abstract:		"Mutations at the Darkener of Apricot (Doa) locus of Drosophila melanogaster alter sexual differentiation by disrupting sex-specific splicing of doublesex pre-mRNA, a key regulator of sex determination. Here, we study the effect of seven Doa alleles and several trans-heterozygous combinations on pheromones and courtship behavior. The cuticular hydrocarbon (CHC) profile was slightly masculinized in females, with an accumulation of shorter compounds (C23 and C25) and a reduction in longer compounds (C27 and C29). The profile was feminized in males. Female cuticular profiles showed fewer dienes and female pheromones in six alleles and in the trans-heterozygotes and showed more male pheromones (tricosene and pentacosene) in three alleles (DEM, E786 and HD) and in all trans-heterozygotes. Courtship was severely affected in Doa males; in particular, males made fewer copulation attempts and copulated less with both control and Doa females. These results suggest that Doa could modulate pheromone production and sex behavior by altering sexual differentiation in the cuticle and the nervous system"
Keywords:		"Animals Courtship Drosophila Proteins/*genetics/metabolism Drosophila melanogaster/genetics/*physiology Female Male Mutation Protein Serine-Threonine Kinases/*genetics/metabolism Sex Attractants/*metabolism *Sexual Behavior, Animal Cuticular hydrocarbons;"
Notes:		"MedlineFumey, Julien Wicker-Thomas, Claude eng England 2017/01/16 J Insect Physiol. 2017 Apr; 98:182-187. doi: 10.1016/j.jinsphys.2017.01.005. Epub 2017 Jan 11"