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Water Sci Technol

Title:		"Effects of pharmaceuticals compounds and calcium on granulation, microbiology, and performance of anaerobic granular sludge systems"
Author(s):		Faria CV; Costa FCR; Jorge AEL; Melo ALP; Silva UCM; Santos VL; Amaral MCS; Fonseca FV;
Address:		"Chemistry School, University of Rio de Janeiro, Horacio Macedo Avenue, 2030, Technology Center, Block E, University City, Rio de Janeiro, Brazil. Engineering School, University of Minas Gerais, Antonio Carlos Avenue, 6627, Belo Horizonte, Brazil E-mail: miriam@desa.ufmg.br. Pontifical Catholic University of Minas Gerais, Dom Jose Gaspar Avenue, 500, Belo Horizonte, Brazil. Microbiology Department, University of Minas Gerais, Antonio Carlos Avenue, 6627, Belo Horizonte, Brazil"
Journal Title:		Water Sci Technol
Year:		2022
Volume:		85
Issue:		11
Page Number:		3184 - 3195
DOI:		10.2166/wst.2022.176
ISSN/ISBN:		0273-1223 (Print) 0273-1223 (Linking)
Abstract:		"Granular sludge is a promising biotechnology to treat sewage contaminated with pharmaceuticals due to its increased toxicity resistance. In this context, this study evaluated the potential of Ca(2+) as a granulation precursor and how pharmaceutical compounds (loratadine, prednisone, fluconazole, fenofibrate, betamethasone, 17alpha-ethinyl estradiol, and ketoprofen) affect granulation. Continuous and intermittent dosages of Ca(2+) in the presence and absence of pharmaceuticals were evaluated. The results showed that intermittent addition of Ca(2+) reduces the time for anaerobic sludge granulation, and pharmaceuticals presence did not impair granulation. 10% of the granules presented mean diameters greater than 2.11 mm within 93 days with intermittent Ca(2+) dosage in the pharmaceuticals' presence. In contrast, no granules higher than 2.0 mm were observed with no precursor addition. The pharmaceuticals' toxicity may have created a stress condition for the microbial community, contributing to more EPS production and a greater potential for granulation. It was also verified that pharmaceuticals' presence did not decrease organic matter, total alkalinity, and volatile fatty acids removals. The 16S rRNA gene analysis revealed taxa resistance to recalcitrant compounds when pharmaceuticals were added. Besides, the efficiency of a granular sludge bioreactor (EGSB) was evaluated for pharmaceuticals removal, and betamethasone, fenofibrate, and prednisone were effectively removed"
Keywords:		"Anaerobiosis Betamethasone Bioreactors/microbiology *Calcium/chemistry Fenofibrate *Pharmaceutical Preparations/chemistry Prednisone RNA, Ribosomal, 16S *Sewage/microbiology *Waste Disposal, Fluid/methods;"
Notes:		"MedlineFaria, Clara V Costa, Flavia C R Jorge, Alexandre E L Melo, Ana Luisa P Silva, Ubiana C M Santos, Vera L Amaral, Miriam C S Fonseca, Fabiana V eng England 2022/06/16 Water Sci Technol. 2022 Jun; 85(11):3184-3195. doi: 10.2166/wst.2022.176"