| Title: | Detection of explosives by olfactory sensory neurons |
| Author(s): | Corcelli A; Lobasso S; Lopalco P; Dibattista M; Araneda R; Peterlin Z; Firestein S; |
| Address: | "Department of Medical Biochemistry, Medical Biology and Medical Physics, University of Bari, Bari, Italy. a.corcelli@biologia.uniba.it" |
| DOI: | 10.1016/j.jhazmat.2009.10.054 |
| ISSN/ISBN: | 1873-3336 (Electronic) 0304-3894 (Linking) |
| Abstract: | "The response of olfactory sensory neurons to TNT and RDX as well as to some volatile organic compounds present in the vapors of antipersonnel landmines has been studied both in the pig and in the rat. GC/MS analyses of different plastic components of six different kinds of landmines were performed in order to identify the components of the 'perfume' of mines. Studies on rat olfactory mucosa were carried out with electro-olfactogram and calcium imaging techniques, while changes in the cyclic adenosine monophosphate (cAMP) levels following exposure to odorants and explosives were used as a criterion to evaluate the interaction of TNT and RDX with olfactory receptors in a preparation of isolated pig olfactory cilia. These studies indicate that chemical compounds associated with explosives and explosive devices can activate mammalian olfactory receptors" |
| Keywords: | "Animals Calcium/metabolism Cyclic AMP/metabolism Explosive Agents/*analysis/metabolism Female Gas Chromatography-Mass Spectrometry/methods Male Models, Chemical Models, Theoretical Neurons, Afferent/metabolism Olfactory Mucosa/metabolism Olfactory Recepto;" |
| Notes: | "MedlineCorcelli, Angela Lobasso, Simona Lopalco, Patrizia Dibattista, Michele Araneda, Ricardo Peterlin, Zita Firestein, Stuart eng Research Support, Non-U.S. Gov't Netherlands 2009/11/17 J Hazard Mater. 2010 Mar 15; 175(1-3):1096-100. doi: 10.1016/j.jhazmat.2009.10.054. Epub 2009 Oct 23" |
