| Title: | Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer |
| Author(s): | van Keulen KE; Jansen ME; Schrauwen RWM; Kolkman JJ; Siersema PD; |
| Address: | "Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Gastroenterology and Hepatology, Medisch Spectrum Twente, Enschede, The Netherlands. University Medical Center Groningen, Groningen, The Netherlands. Department of Gastroenterology and Hepatology, Bernhoven, Uden, The Netherlands" |
| ISSN/ISBN: | 1365-2036 (Electronic) 0269-2813 (Print) 0269-2813 (Linking) |
| Abstract: | "BACKGROUND: Colorectal cancer (CRC) is the third most common cancer diagnosis in the Western world. AIM: To evaluate exhaled volatile organic compounds (VOCs) as a non-invasive biomarker for the detection of CRC and precursor lesions using an electronic nose. METHODS: In this multicentre study adult colonoscopy patients, without inflammatory bowel disease or (previous) malignancy, were invited for breath analysis. Two-thirds of the breath tests were randomly assigned to develop training models which were used to predict the diagnosis of the remaining patients (external validation). In the end, all data were used to develop final-disease models to further improve the discriminatory power of the algorithms. RESULTS: Five hundred and eleven breath samples were collected. Sixty-four patients were excluded due to an inadequate breath test (n = 51), incomplete colonoscopy (n = 8) or colitis (n = 5). Classification was based on the most advanced lesion found; CRC (n = 70), advanced adenomas (AAs) (n = 117), non-advanced adenoma (n = 117), hyperplastic polyp (n = 15), normal colonoscopy (n = 125). Training models for CRC and AAs had an area under the curve (AUC) of 0.76 and 0.71 and blind validation resulted in an AUC of 0.74 and 0.61 respectively. Final models for CRC and AAs yielded an AUC of 0.84 (sensitivity 95% and specificity 64%) and 0.73 (sensitivity and specificity 79% and 59%) respectively. CONCLUSIONS: This study suggests that exhaled VOCs could potentially serve as a non-invasive biomarker for the detection of CRC and AAs. Future studies including more patients could further improve the discriminatory potential of VOC analysis for the detection of (pre-)malignant colorectal lesions. (https://clinicaltrials.gov Identifier NCT03488537)" |
| Keywords: | "Adenoma/*diagnosis/metabolism/pathology Aged Biomarkers, Tumor/*analysis/metabolism Breath Tests/instrumentation/methods Case-Control Studies Colonoscopy Colorectal Neoplasms/*diagnosis/metabolism/pathology Cross-Sectional Studies Disease Progression *Ear;" |
| Notes: | "Medlinevan Keulen, Kelly E Jansen, Maud E Schrauwen, Ruud W M Kolkman, Jeroen J Siersema, Peter D eng Evaluation Study Multicenter Study England 2019/12/21 Aliment Pharmacol Ther. 2020 Feb; 51(3):334-346. doi: 10.1111/apt.15622. Epub 2019 Dec 20" |
