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Respirology

Title:		The impact of antenatal and postnatal indoor air pollution or tobacco smoke exposure on lung function at 3 years in an African birth cohort
Author(s):		Chaya S; Vanker A; Brittain K; MacGinty R; Jacobs C; Hantos Z; Zar HJ; Gray DM;
Address:		"Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary"
Journal Title:		Respirology
Year:		2023
Volume:		20230817
Issue:
Page Number:		-
DOI:		10.1111/resp.14576
ISSN/ISBN:		1440-1843 (Electronic) 1323-7799 (Linking)
Abstract:		"BACKGROUND AND OBJECTIVE: Indoor air pollution (IAP) and tobacco smoke exposure (ETS) are global health concerns contributing to the burden of childhood respiratory disease. Studies assessing the effects of IAP and ETS in preschool children are limited. We assessed the impact of antenatal and postnatal IAP and ETS exposure on lung function in a South African birth cohort, the Drakenstein Child Health Study. METHODS: Antenatally enrolled mother-child pairs were followed from birth. Lung function measurements (oscillometry, multiple breath washout and tidal breathing) were performed at 6 weeks and 3 years. Quantitative antenatal and postnatal IAP (particulate matter [PM(10) ], volatile organic compounds [VOC]) and ETS exposures were measured. Linear regression models explored the effects of antenatal and postnatal exposures on lung function at 3 years. RESULTS: Five hundred eighty-four children had successful lung function testing, mean (SD) age of 37.3 (0.7) months. Exposure to antenatal PM(10) was associated with a decreased lung clearance index (p < 0.01) and postnatally an increase in the difference between resistance at end expiration (ReE) and inspiration (p = 0.05) and decrease in tidal volume (p = 0.06). Exposure to antenatal VOC was associated with an increase in functional residual capacity (p = 0.04) and a decrease in time of expiration over total breath time (t(E) /t(TOT) ) (p = 0.03) and postnatally an increase in respiratory rate (p = 0.05). High ETS exposure postnatally was associated with an increase in ReE (p = 0.03). CONCLUSION: Antenatal and postnatal IAP and ETS exposures were associated with impairment in lung function at 3 years. Strengthened efforts to reduce IAP and ETS exposure are needed"
Keywords:		childhood lung function environmental tobacco smoke indoor air pollution multiple breath washout oscillometry tidal breathing flow volume loop;
Notes:		"PublisherChaya, S Vanker, A Brittain, K MacGinty, R Jacobs, C Hantos, Z Zar, H J Gray, D M eng 098479/Z/12/Z/WT_/Wellcome Trust/United Kingdom 204755/Z/162/WT_/Wellcome Trust/United Kingdom Australia 2023/08/17 Respirology. 2023 Aug 17. doi: 10.1111/resp.14576"