| Title: | A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship |
| Address: | "Institute of Biochemistry, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland" |
| DOI: | 10.1016/j.cell.2013.10.046 |
| ISSN/ISBN: | 1097-4172 (Electronic) 0092-8674 (Linking) |
| Abstract: | "Cellular behavior is frequently influenced by the cell's history, indicating that single cells may memorize past events. We report that budding yeast permanently escape pheromone-induced cell-cycle arrest when experiencing a deceptive mating attempt, i.e., not reaching their putative partner within reasonable time. This acquired behavior depends on super-assembly and inactivation of the G1/S inhibitor Whi3, which liberates the G1 cyclin Cln3 from translational inhibition. Super-assembly of Whi3 is a slow response to pheromone, driven by polyQ and polyN domains, counteracted by Hsp70, and stable over generations. Unlike prion aggregates, Whi3 super-assemblies are not inherited mitotically but segregate to the mother cell. We propose that such polyQ- and polyN-based elements, termed here mnemons, act as cellular memory devices to encode previous environmental conditions" |
| Keywords: | "Adaptation, Biological Adenosine Triphosphatases/metabolism Cell Cycle Cyclins/chemistry/metabolism HSP70 Heat-Shock Proteins/metabolism Pheromones/*metabolism Protein Structure, Tertiary RNA-Binding Proteins/chemistry/*metabolism Receptors, Mating Factor;" |
| Notes: | "MedlineCaudron, Fabrice Barral, Yves eng Research Support, Non-U.S. Gov't 2013/12/10 Cell. 2013 Dec 5; 155(6):1244-57. doi: 10.1016/j.cell.2013.10.046" |
