| Title: | Indoor volatile organic compounds exposures and risk of childhood acute leukemia: a case-control study in shanghai |
| Author(s): | Zhang Y; Chen D; Shi R; Kamijima M; Sakai K; Tian Y; Gao Y; |
| Address: | "Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University school of Medicine, Shanghai, China. Department of School Health, Minhang District Center for Disease Control and Prevention, Shanghai, China. Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan. MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China" |
| Journal Title: | J Environ Sci Health A Tox Hazard Subst Environ Eng |
| DOI: | 10.1080/10934529.2020.1861903 |
| ISSN/ISBN: | 1532-4117 (Electronic) 1093-4529 (Linking) |
| Abstract: | "A case-control study was conducted to investigate the relationship between indoor air pollution and childhood acute leukemia (AL) in Shanghai. 97 cases and 148 gender-, age-, and residence-matched controls were included. Indoor air pollution was evaluated by questionnaires and quantitative measurement including 14 volatile organic compounds (VOCs) and nitrogen dioxide (NO(2)) in the homes of the two groups. The levels of individual VOCs, VOC families, TVOC (sum of the concentrations of the individual VOCs) and NO(2) were compared between the two groups. Exposure to styrene and butyl alcohol were associated with an increased risk of childhood AL (styrene: odds ratio (OR)=2.33, 95% confidence interval (CI): 1.07-5.07; butyl alcohol: OR = 2.51, 95%CI: 1.19-5.28); 4th quartile of chlorinated hydrocarbons (OR = 2.52, 95%CI: 1.02-6.26) and 3rd quartile of TVOC (OR = 4.03, 95%CI: 1.06-6.81) had significant higher ORs for childhood AL compared with that in the lowest quartiles. Elevated levels of individual VOCs, VOC families and TVOC were also associated with self-reported risk factors. Our findings suggest that VOCs exposure was associated with an elevated risk of childhood AL, underscore that more attention should be paid to indoor air pollution as a risk factor of childhood AL" |
| Keywords: | "Air Pollutants/*analysis Air Pollution, Indoor/*analysis Case-Control Studies Child China Environmental Monitoring/methods Female Housing/standards Humans Male Nitrogen Dioxide/*analysis Precursor Cell Lymphoblastic Leukemia-Lymphoma/*epidemiology Risk Fa;" |
| Notes: | "MedlineZhang, Yan Chen, Didi Shi, Rong Kamijima, Michihiro Sakai, Kiyoshi Tian, Ying Gao, Yu eng England 2020/12/29 J Environ Sci Health A Tox Hazard Subst Environ Eng. 2021; 56(2):190-198. doi: 10.1080/10934529.2020.1861903. Epub 2020 Dec 26" |
