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World J Diabetes

Title:		Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus
Author(s):		Sana SR; Chen GM; Lv Y; Guo L; Li EY;
Address:		"Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. lienyou_1111@163.com"
Journal Title:		World J Diabetes
Year:		2022
Volume:		13
Issue:		10
Page Number:		888 - 899
DOI:		10.4239/wjd.v13.i10.888
ISSN/ISBN:		1948-9358 (Print) 1948-9358 (Electronic) 1948-9358 (Linking)
Abstract:		"BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disease with an increasing annual incidence rate. Our previous observational study found that pregnant women with GDM had mild cognitive decline. AIM: To analyze the changes in metabonomics in pregnant women with GDM and explore the mechanism of cognitive function decline. METHODS: Thirty GDM patients and 30 healthy pregnant women were analyzed. Solid-phase microextraction gas chromatography/mass spectrometry was used to detect organic matter in plasma and urine samples. Statistical analyses were conducted using principal component analysis and partial least squares discriminant analysis. RESULTS: Differential volatile metabolites in the serum of pregnant women with GDM included hexanal, 2-octen-1-ol, and 2-propanol. Differential volatile metabolites in the urine of these women included benzene, cyclohexanone, 1-hexanol, and phenol. Among the differential metabolites, the conversion of 2-propanol to acetone may further produce methylglyoxal. Therefore, 2-propanol may be a potential marker for serum methylglyoxal. CONCLUSION: 2-propanol may be a potential volatile marker to evaluate cognitive impairment in pregnant women with GDM"
Keywords:		2-propanol Gas chromatography/mass spectrometry Gestational diabetes mellitus Humoral biomarkers;
Notes:		"PubMed-not-MEDLINESana, Si-Ri-Gu-Leng Chen, Guang-Min Lv, Yang Guo, Lei Li, En-You eng Clinical Trial 2022/11/01 World J Diabetes. 2022 Oct 15; 13(10):888-899. doi: 10.4239/wjd.v13.i10.888"