« Previous AbstractCell death and mitochondrial dysfunction induced by the dietary non-proteinogenic amino acid L-azetidine-2-carboxylic acid (Aze)    Next Abstract[The genital control of cattle] »

Sci Total Environ

Title:		Associations between urinary biomarkers of oxidative stress and biomarkers of tobacco smoke exposure in smokers
Author(s):		Sambiagio N; Berthet A; Wild P; Sauvain JJ; Auer R; Schoeni A; Rodondi N; Feller M; Humair JP; Berlin I; Breider F; Grandjean D; Hopf NB;
Address:		"Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: nicolas.sambiagio@unisante.ch. Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: aurelie.berthet@unisante.ch. Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: pascal@pw-statistical-consulting.eu. Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: jeanjacques.sauvain@unisante.ch. Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland. Electronic address: reto.auer@biham.unibe.ch. Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland. Electronic address: anna.schoeni@biham.unibe.ch. Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland; Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland. Electronic address: nicolas.rodondi@biham.unibe.ch. Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland; Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland. Department of Primary Care Medicine, Geneva University Hospitals, Rue Gabrielle Perret-Gentil 4, 1211 Geneva, Switzerland. Electronic address: jean-paul.humair@hcuge.ch. Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland; Department of Pharmacology, Assistance Publique-Hopitaux de Paris, Sorbonne University, 75013 Paris, France. Electronic address: ivan.berlin@aphp.fr. Central Environmental Laboratory (GR-CEL), Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. Electronic address: florian.breider@epfl.ch. Central Environmental Laboratory (GR-CEL), Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. Electronic address: dominique.grandjean@epfl.ch. Center for Primary Care and Public Health (Unisante), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: nancy.hopf@unisante.ch"
Journal Title:		Sci Total Environ
Year:		2022
Volume:		20220902
Issue:
Page Number:		158361 -
DOI:		10.1016/j.scitotenv.2022.158361
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"Oxidative stress can contribute to the development of diseases, and may originate from exposures to toxicants commonly found in air pollution and cigarette smoke such as polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). Yet, associations between these exposures and oxidative stress biomarkers are poorly characterized. We report here novel associations between 14 exposure biomarkers of PAHs and VOCs, and two oxidative stress biomarkers; 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-isoprostaglandin F(2alpha) (8-isoprostane) in urine obtained from smokers participating in an ongoing clinical study (ESTxENDS, NCT03589989). We also assessed associations between six biomarkers of tobacco smoke exposure (metabolites of nicotine and tobacco-specific nitrosamines (TSNAs)) and both oxidative stress biomarkers. We then quantified the relative importance of each family of the 20 exposure biomarkers on oxidative stress. Participating smokers (153 men and 117 women, median age 44 years) had on average smoked 25 [2-62] years and smoked about 17 [5-40] cigarettes per day at the time of the study. Multiple linear regression results showed an association between 8-oxodG concentrations and the following metabolites in decreasing relative importance: PAHs (beta coefficient beta = 0.105, p-value <0.001, partial R(2) = 0.15) > VOCs (beta = 0.028, p < 0.001, partial R(2) = 0.09) > nicotine (beta = 0.226, p < 0.001, partial R(2) = 0.08); and between 8-isoprostane concentrations and metabolites of PAHs (beta = 0.117, p < 0.001, partial R(2) = 0.14) > VOCs (beta = 0.040, p < 0.001, partial R(2) = 0.14) > TSNAs (beta = 0.202, p = 0.003, partial R(2) = 0.09) > nicotine (beta = 0.266, p < 0.001, partial R(2) = 0.08). Behavioral factors known to contribute to oxidative stress, including sleep quality, physical activity, and alcohol consumption, did not play a significant role. Exposures to PAHs and VOCs among smokers were significantly associated with oxidative stress"
Keywords:		Adult Female Humans Male 8-Hydroxy-2'-Deoxyguanosine Biomarkers/urine Nicotine/analysis *Nitrosamines/urine Oxidative Stress *Polycyclic Aromatic Hydrocarbons/analysis Smokers *Tobacco Smoke Pollution/analysis *Volatile Organic Compounds/analysis Air poll;
Notes:		"MedlineSambiagio, Nicolas Berthet, Aurelie Wild, Pascal Sauvain, Jean-Jacques Auer, Reto Schoeni, Anna Rodondi, Nicolas Feller, Martin Humair, Jean-Paul Berlin, Ivan Breider, Florian Grandjean, Dominique Hopf, Nancy B eng Clinical Trial Netherlands 2022/09/05 Sci Total Environ. 2022 Dec 15; 852:158361. doi: 10.1016/j.scitotenv.2022.158361. Epub 2022 Sep 2"