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Proc Natl Acad Sci U S A

Title:		MIPs are ancestral ligands for the sex peptide receptor
Author(s):		Kim YJ; Bartalska K; Audsley N; Yamanaka N; Yapici N; Lee JY; Kim YC; Markovic M; Isaac E; Tanaka Y; Dickson BJ;
Address:		"Research Institute of Molecular Pathology, A-1030 Vienna, Austria. kimyj@gist.ac.kr"
Journal Title:		Proc Natl Acad Sci U S A
Year:		2010
Volume:		20100322
Issue:		14
Page Number:		6520 - 6525
DOI:		10.1073/pnas.0914764107
ISSN/ISBN:		1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking)
Abstract:		"Upon mating, females of many animal species undergo dramatic changes in their behavior. In Drosophila melanogaster, postmating behaviors are triggered by sex peptide (SP), which is produced in the male seminal fluid and transferred to female during copulation. SP modulates female behaviors via sex peptide receptor (SPR) located in a small subset of internal sensory neurons that innervate the female uterus and project to the CNS. Although required for postmating responses only in these female sensory neurons, SPR is expressed broadly in the CNS of both sexes. Moreover, SPR is also encoded in the genomes of insects that lack obvious SP orthologs. These observations suggest that SPR may have additional ligands and functions. Here, we identify myoinhibitory peptides (MIPs) as a second family of SPR ligands that is conserved across a wide range of invertebrate species. MIPs are potent agonists for Drosophila, Aedes, and Aplysia SPRs in vitro, yet are unable to trigger postmating responses in vivo. In contrast to SP, MIPs are not produced in male reproductive organs, and are not required for postmating behaviors in Drosophila females. We conclude that MIPs are evolutionarily conserved ligands for SPR, which are likely to mediate functions other than the regulation of female reproductive behaviors"
Keywords:		"Amino Acid Sequence Animals CHO Cells Central Nervous System/metabolism Consummatory Behavior Cricetinae Cricetulus Drosophila Proteins/agonists/genetics/*metabolism Drosophila melanogaster/chemistry/genetics/*metabolism Female Ligands Male Models, Molecu;"
Notes:		"MedlineKim, Young-Joon Bartalska, Katarina Audsley, Neil Yamanaka, Naoki Yapici, Nilay Lee, Ju-Youn Kim, Yong-Chul Markovic, Milica Isaac, Elwyn Tanaka, Yoshiaki Dickson, Barry J eng Research Support, Non-U.S. Gov't 2010/03/24 Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14):6520-5. doi: 10.1073/pnas.0914764107. Epub 2010 Mar 22"