| Title: | Expression of candidate pheromone receptor genes in vomeronasal neurons |
| Address: | "Howard Hughes Medical Institute, Cambridge, MA, USA. dulac@fas.harvard.edu" |
| ISSN/ISBN: | 0379-864X (Print) 0379-864X (Linking) |
| Abstract: | "In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VON). Pheromones activate the VNO and elicit a characteristic array of innate reproductive and social behaviors, along with dramatic neuroendocrine responses. Recent approaches have provided new insights into the molecular biology of sensory transduction in the VNO. Differential screening of cDNA libraries constructed from single sensory neurons from the rat VNO has led to the isolation of a family of genes which are likely to encode mammalian pheromone receptors. The isolation of these receptors from the VNO might permit the analysis of the molecular events which translate the bindings of pheromones into innate stereotypic behaviors and help to elucidate the logic of pheromone perception in mammals" |
| Keywords: | "Amino Acid Sequence Animals Chemoreceptor Cells/*physiology Gene Expression Humans Molecular Sequence Data Neurons/*metabolism Rats Sequence Homology, Amino Acid Vomeronasal Organ/*metabolism;" |
| Notes: | "MedlineDulac, C Axel, R eng Review England 1998/10/06 Chem Senses. 1998 Aug; 23(4):467-75. doi: 10.1093/chemse/23.4.467" |
