« Previous AbstractWestern pine beetle: specificity among enantiomers of male and female components of an attractant pheromone    Next AbstractThinking about networks in the control of male hamster sexual behavior »

Gene

Title:		The phzI gene of Pseudomonas aureofaciens 30-84 is responsible for the production of a diffusible signal required for phenazine antibiotic production
Author(s):		Wood DW; Pierson LS;
Address:		"Department of Plant Pathology, University of Arizona, Tucson, 85721, USA"
Journal Title:		Gene
Year:		1996
Volume:		168
Issue:		1
Page Number:		49 - 53
DOI:		10.1016/0378-1119(95)00754-7
ISSN/ISBN:		0378-1119 (Print) 0378-1119 (Linking)
Abstract:		"The production of phenazine (Ph) antibiotics in Pseudomonas aureofaciens (Pau) 30-84 is positively regulated by PhzR, a protein belonging to the LuxR family of transcriptional activators. We have now identified phzI, a second gene required for PH production. The product of phzI is a member of the LuxI family of N-acyl-homoserine lactone (N-acyl-HSL) synthases. Inactivation of phzI results in the loss of Ph production in Pau 30-84. The presence of phzI in Escherichia coli is sufficient for the production of a diffusible signal which activates phzB expression in Pau 30-84 and traA expression in a N-acyl-HSL-dependent reporter strain of Agrobacterium tumefaciens. In addition, synthetic N-(3-oxohexanoyl)-L-HSL induces phzB expression in Pau 30-84. These results suggest that Pau 30-84 produces a N-acyl-HSL signal that regulates Ph production, and that phzI plays a central role in this signaling pathway"
Keywords:		4-Butyrolactone/analogs & derivatives/metabolism/pharmacology Anti-Bacterial Agents/*biosynthesis/pharmacology Bacterial Proteins/chemistry/*genetics/metabolism/physiology Base Sequence Cell Division/genetics DNA-Binding Proteins/genetics/metabolism Esche;
Notes:		"MedlineWood, D W Pierson, L S 3rd eng Research Support, U.S. Gov't, Non-P.H.S. Netherlands 1996/02/02 Gene. 1996 Feb 2; 168(1):49-53. doi: 10.1016/0378-1119(95)00754-7"