| Title: | "Volatiles, a glutarimide alkaloid and antimicrobial effects of Croton pullei (Euphorbiaceae)" |
| Author(s): | Peixoto RN; Guilhon GM; das Gracas BZ; Araujo IS; Uetanabaro AP; Santos LS; do SBB; |
| Address: | "Programa de Pos-graduacao em Quimica, Universidade Federal do Para, Av. Augusto Correa 01, 66075-110, Belem-PA, Brazil. rosana.nsp@gmail.com" |
| DOI: | 10.3390/molecules18033195 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Chemical investigation of Croton pullei (Euphorbiaceae) collected in the Brazilian Amazon region was revisited. The chemical composition of the essential oils of leaves and stems was analyzed by GC/MS. It was found that both the oils comprise mainly terpenes, among which linalool was the major one (24.90 and 39.72%, respectively). Phytochemical investigation of the stem methanol extract led to the isolation of a new natural product from the glutarimide alkaloid group named N-[2,6-dioxo-1-(2-phenylethyl)-3-piperidinyl]-acetamide, confirming that C. pullei is a rich source of this class of alkaloids. The hexane and methanol extracts of the stems of C. pullei showed moderate antibacterial and antifungal activity and the highest inhibition was observed when the methanol extract was tested against Staphylococcus aureus CCMB 262 and CCMB 263" |
| Keywords: | "Alkaloids/*chemistry/*pharmacology Anti-Infective Agents/*chemistry/*pharmacology Croton/*chemistry Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Parasitic Sensitivity Tests Piperidones/*chemistry Plant Extracts/;" |
| Notes: | "MedlinePeixoto, Rosana N S Guilhon, Giselle M S P das Gracas B Zoghbi, Maria Araujo, Isabella S Uetanabaro, Ana Paula T Santos, Lourivaldo S do S B Brasil, Davi eng Research Support, Non-U.S. Gov't Switzerland 2013/03/14 Molecules. 2013 Mar 12; 18(3):3195-205. doi: 10.3390/molecules18033195" |
