| Title: | Processing and export of peptide pheromones and bacteriocins in Gram-negative bacteria |
| Author(s): | Michiels J; Dirix G; Vanderleyden J; Xi C; |
| Address: | "Center of Microbial and Plant Genetics, Kasteelpark Arenberg 20, B-3001, Heverlee, Belgium. jan.michels@agr.kuleuven.ac.be" |
| DOI: | 10.1016/s0966-842x(01)01979-5 |
| ISSN/ISBN: | 0966-842X (Print) 0966-842X (Linking) |
| Abstract: | "Cell-density-dependent gene expression is widespread in bacteria and is mediated by extracellular communication molecules. Gram-negative bacteria often use N-acyl homoserine lactones, whereas cell-cell signaling in Gram-positive bacteria is accomplished using post-translationally processed peptide pheromones. In many Gram-positive bacteria, export of these peptides requires the activity of a dedicated ATP-binding cassette (ABC) transporter, which cleaves off a typical leader peptide termed the double-glycine leader sequence concomitant with translocation across the membrane. Inspection of bacterial genome sequences has revealed the presence of similar ABC transporters, as well as genes encoding peptides with double-glycine-type leader sequences in Gram-negative bacteria, and it is suggested that the postulated transported peptides could perform a signaling function" |
| Keywords: | "ATP-Binding Cassette Transporters/genetics/*metabolism Amino Acid Sequence Bacteriocins/*metabolism Gene Expression Regulation, Bacterial Gram-Negative Bacteria/*metabolism Molecular Sequence Data Peptides/*metabolism Pheromones/*metabolism Protein Sortin;" |
| Notes: | "MedlineMichiels, J Dirix, G Vanderleyden, J Xi, C eng Research Support, Non-U.S. Gov't Review England 2001/04/05 Trends Microbiol. 2001 Apr; 9(4):164-8. doi: 10.1016/s0966-842x(01)01979-5" |
