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PLoS One

Title:		Use of fecal volatile organic compound analysis to discriminate between non-vaccinated and BCG-Vaccinated cattle prior to and after Mycobacterium bovis challenge
Author(s):		Ellis CK; Rice S; Maurer D; Stahl R; Waters WR; Palmer MV; Nol P; Rhyan JC; VerCauteren KC; Koziel JA;
Address:		"United States Department of Agriculture, Animal Plant and Health Inspection Service, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado, United States of America. Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, Iowa, United States of America. United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa, United States of America. United States Department of Agriculture, Animal Plant and Health Inspection Service, Veterinary Services, Wildlife Livestock Disease Investigations Team, Fort Collins, Colorado, United States of America"
Journal Title:		PLoS One
Year:		2017
Volume:		20170707
Issue:		7
Page Number:		e0179914 -
DOI:		10.1371/journal.pone.0179914
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		Bovine tuberculosis is a zoonotic disease of global public health concern. Development of diagnostic tools to improve test accuracy and efficiency in domestic livestock and enable surveillance of wildlife reservoirs would improve disease management and eradication efforts. Use of volatile organic compound analysis in breath and fecal samples is being developed and optimized as a means to detect disease in humans and animals. In this study we demonstrate that VOCs present in fecal samples can be used to discriminate between non-vaccinated and BCG-vaccinated cattle prior to and after Mycobacterium bovis challenge
Keywords:		"Animals;Animals Animals, Domestic Animals, Wild *BCG Vaccine Cattle Feces/*microbiology Humans Mycobacterium bovis/isolation & purification/pathogenicity Tuberculosis, Bovine/microbiology/*prevention & control Volatile Organic Compounds/*isolation & purification;"
Notes:		"MedlineEllis, Christine K Rice, Somchai Maurer, Devin Stahl, Randal Waters, W Ray Palmer, Mitchell V Nol, Pauline Rhyan, Jack C VerCauteren, Kurt C Koziel, Jacek A eng 2017/07/08 PLoS One. 2017 Jul 7; 12(7):e0179914. doi: 10.1371/journal.pone.0179914. eCollection 2017"