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Sci Total Environ
Title: | "Long-term exposure to ambient air pollution and autism spectrum disorder in children: A case-control study in Tehran, Iran" |
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Author(s): | Yousefian F; Mahvi AH; Yunesian M; Hassanvand MS; Kashani H; Amini H; |
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Address: | "Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Air Pollution Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: ahmahvi@yahoo.com. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: yunesian@tums.ac.ir. Center for Air Pollution Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland" |
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Journal Title: | Sci Total Environ |
Year: | 2018 |
Volume: | 20180704 |
Issue: | |
Page Number: | 1216 - 1222 |
DOI: | 10.1016/j.scitotenv.2018.06.259 |
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ISSN/ISBN: | 1879-1026 (Electronic) 0048-9697 (Linking) |
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Abstract: | "Some recent human and animal studies have suggested that air pollution may affect the central nervous system and contribute to neurodevelopmental outcomes, such as autism spectrum disorder (ASD). We aimed to investigate the association between long-term exposure to ambient air pollution and increased odds of ASD among 2 to 10-year-old children. We conducted a case-control study in Tehran, Iran. Cases were 134 children born between 2004 and 2012 diagnosed with ASD whose mothers were resident in Tehran during their pregnancy, and controls were 388 children without ASD randomly selected from public schools and kindergartens. Land-use regression models were used to estimate their annual mean exposure to ambient particulate matter with aerodynamic diameter =10?ª+mum (PM(10)), sulfur dioxide (SO(2)), benzene, toluene, ethylbenzene, p-xylene, o-xylene, m-xylene (BTEX), and total BTEX. Logistic regression was used for the analyses and adjusted for possible confounding variables. The odds ratios per 1 unit increase in pollutants in the adjusted models were 1.00 (95% CI: 0.99, 1.01) for PM(10), 0.99 (95% CI: 0.99, 1.00) for SO(2), 0.96 (0.83, 1.11) for benzene, 1.00 (0.96, 1.04) for toluene, 0.95 (0.79, 1.16) for ethylbenzene, 1.00 (0.78, 1.27) for p-xylene, 1.09 (0.94, 1.27) for o-xylene, 1.01 (0.92, 1.12) for m-xylene, and 0.99 (0.97, 1.01) for total BTEX. We did not find the evidence of association between estimated annual mean exposure to abovementioned ambient air pollutants and increased odds of ASD in children. However, our findings might be due to some important limitations. Further research with better control of confounding variables, improved spatiotemporal exposure estimates, and inclusion of other important markers of air pollution is recommended" |
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Keywords: | "Air Pollutants Air Pollution/*statistics & numerical data Autism Spectrum Disorder/*epidemiology Case-Control Studies Child Child, Preschool Environmental Exposure/*statistics & numerical data Environmental Monitoring Humans Iran/epidemiology Particulate;" |
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Notes: | "MedlineYousefian, Fatemeh Mahvi, Amir Hossein Yunesian, Masud Hassanvand, Mohammad Sadegh Kashani, Homa Amini, Heresh eng Netherlands 2018/09/08 Sci Total Environ. 2018 Dec 1; 643:1216-1222. doi: 10.1016/j.scitotenv.2018.06.259. Epub 2018 Jul 4" |
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Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
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