| Title: | Odor coding in the antenna of the tsetse fly Glossina morsitans |
| Author(s): | Soni N; Chahda JS; Carlson JR; |
| Address: | "Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 john.carlson@yale.edu" |
| ISSN/ISBN: | 1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking) |
| Abstract: | "Tsetse flies transmit trypanosomiasis to humans and livestock across much of sub-Saharan Africa. Tsetse are attracted by olfactory cues emanating from their hosts. However, remarkably little is known about the cellular basis of olfaction in tsetse. We have carried out a systematic physiological analysis of the Glossina morsitans antenna. We identify 7 functional classes of olfactory sensilla that respond to human or animal odorants, CO(2), sex and alarm pheromones, or other odorants known to attract or repel tsetse. Sensilla differ in their response spectra, show both excitatory and inhibitory responses, and exhibit different response dynamics to different odor stimuli. We find striking differences between the functional organization of the tsetse fly antenna and that of the fruit fly Drosophila melanogaster One morphological type of sensilla has a different function in the 2 species: Trichoid sensilla respond to pheromones in Drosophila but respond to a wide diversity of compounds in G. morsitans. In contrast to Drosophila, all tested G. morsitans sensilla that show excitatory responses are excited by one odorant, 1-octen-3-ol, which is contained in host emanations. The response profiles of some classes of sensilla are distinct but strongly correlated, unlike the organization described in the Drosophila antenna. Taken together, this study defines elements that likely mediate the attraction of tsetse to its hosts and that might be manipulated as a means of controlling the fly and the diseases it transmits" |
| Keywords: | Animals Arthropod Antennae/metabolism/physiology Carbon Dioxide/chemistry/metabolism Drosophila melanogaster/genetics/physiology Humans Octanols/chemistry/*metabolism Odorants/*analysis Sensilla/chemistry/metabolism Sex Attractants/*genetics/metabolism Sm; |
| Notes: | "MedlineSoni, Neeraj Chahda, J Sebastian Carlson, John R eng F32 DC015969/DC/NIDCD NIH HHS/ U01 AI115648/AI/NIAID NIH HHS/ R01 DC002174/DC/NIDCD NIH HHS/ R01 DC004729/DC/NIDCD NIH HHS/ R01 DC011697/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural 2019/06/22 Proc Natl Acad Sci U S A. 2019 Jul 9; 116(28):14300-14308. doi: 10.1073/pnas.1907075116. Epub 2019 Jun 20" |
