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Mol Cell Endocrinol

Title:		GnRH neurogenesis depends on embryonic pheromone receptor expression
Author(s):		Schmid T; Boehm U; Braun T;
Address:		"Max-Planck-Institute for Heart and Lung Research, 61231, Bad Nauheim, Ludwigstr. 43, Germany. Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany. Electronic address: ulrich.boehm@uks.eu. Max-Planck-Institute for Heart and Lung Research, 61231, Bad Nauheim, Ludwigstr. 43, Germany; Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina. Electronic address: thomas.braun@mpi-bn.mpg.de"
Journal Title:		Mol Cell Endocrinol
Year:		2020
Volume:		20200912
Issue:
Page Number:		111030 -
DOI:		10.1016/j.mce.2020.111030
ISSN/ISBN:		1872-8057 (Electronic) 0303-7207 (Linking)
Abstract:		"Gonadotropin-releasing hormone (GnRH) neurons control mammalian reproduction and migrate from their birthplace in the nasal placode to the hypothalamus during development. Despite much work on the origin and migration of GnRH neurons, the processes that control GnRH lineage formation are not fully understood. Here, we demonstrate that Nhlh genes control vomeronasal receptor expression in the developing murine olfactory placode associated with the generation of the first GnRH neurons at embryonic days (E)10-12. Inactivation of ss2-microglobulin (ss2-m), which selectively affects surface expression of V2Rs, dramatically decreased the number of GnRH neurons in the Nhlh2 mutant background, preventing rescue of fertility in female Nhlh2 mutant mice by male pheromones. In addition, we show that GnRH neurons generated after E12 fail to establish synaptic connections to the vomeronasal amygdala, suggesting the existence of functionally specialized subpopulations of GnRH neurons, which process pheromonal information"
Keywords:		"Animals Basic Helix-Loop-Helix Transcription Factors/genetics Cells, Cultured Chemotactic Factors/genetics Embryo, Mammalian Female Gene Expression Regulation, Developmental Gonadotropin-Releasing Hormone/*metabolism Hypothalamus/embryology/metabolism Mal;"
Notes:		"MedlineSchmid, Thomas Boehm, Ulrich Braun, Thomas eng Research Support, Non-U.S. Gov't Ireland 2020/09/16 Mol Cell Endocrinol. 2020 Dec 1; 518:111030. doi: 10.1016/j.mce.2020.111030. Epub 2020 Sep 12"