| Title: | "Helikauranoside a, a new bioactive diterpene" |
| Author(s): | Macias FA; Lopez A; Varela RM; Torres A; Molinillo JM; |
| Address: | "Grupo de Alelopatia, Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cadiz, C/ Republica Saharaui s/n, Apdo. 40, 11510, Puerto Real, Cadiz, Spain. famacias@uca.es" |
| DOI: | 10.1007/s10886-007-9400-4 |
| ISSN/ISBN: | 0098-0331 (Print) 0098-0331 (Linking) |
| Abstract: | "A new ent-kaurane glucoside, named helikauranoside A (4), was isolated from the aerial parts of Helianthus annuus L. together with three known ent-kaurane-type diterpenoids: (-)-kaur-16-en-19-oic acid (1), grandifloric acid (2), and paniculoside IV (3). The structure of 4 was determined by using a combination of 1D (1H-NMR and 13C-NMR) and 2D (COSY, HSQC, and HMBC) NMR techniques. Bioactivity spectra of isolated compounds were tested by using the etiolated wheat coleoptile bioassay in aqueous solutions at concentrations ranging from 10(-3) to 10(-6)M. Helikauranoside A (4) was the most active (-84%, 10(-3)M; -56%, 10(-4)M). These results suggest that this new compound may be involved in defense mechanisms of H. annuus" |
| Keywords: | Diterpenes/*analysis/*pharmacology Helianthus/*chemistry Magnetic Resonance Spectroscopy Pheromones/analysis/pharmacology Plant Extracts/analysis/pharmacology Plant Leaves/chemistry Triticum/*drug effects/growth & development; |
| Notes: | "MedlineMacias, Francisco A Lopez, Adriana Varela, Rosa M Torres, Ascension Molinillo, Jose M G eng Research Support, Non-U.S. Gov't 2007/12/12 J Chem Ecol. 2008 Jan; 34(1):65-9. doi: 10.1007/s10886-007-9400-4. Epub 2007 Dec 11" |
