| Title: | Feeding regulates sex pheromone attraction and courtship in Drosophila females |
| Author(s): | Lebreton S; Trona F; Borrero-Echeverry F; Bilz F; Grabe V; Becher PG; Carlsson MA; Nassel DR; Hansson BS; Sachse S; Witzgall P; |
| Address: | "1] Swedish University of Agricultural Sciences, Department of Plant Protection Biology, Division of Chemical Ecology, Alnarp, Sweden [2] Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, Germany. 1] Swedish University of Agricultural Sciences, Department of Plant Protection Biology, Division of Chemical Ecology, Alnarp, Sweden [2] Colombian Corporation of Agricultural Research Research CORPOICA, Biological Control Laboratory, Las Palmas 240142, Colombia. Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, Germany. Swedish University of Agricultural Sciences, Department of Plant Protection Biology, Division of Chemical Ecology, Alnarp, Sweden. Department of Zoology, Stockholm University, Stockholm, Sweden" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "In Drosophila melanogaster, gender-specific behavioural responses to the male-produced sex pheromone cis-vaccenyl acetate (cVA) rely on sexually dimorphic, third-order neural circuits. We show that nutritional state in female flies modulates cVA perception in first-order olfactory neurons. Starvation increases, and feeding reduces attraction to food odour, in both sexes. Adding cVA to food odour, however, maintains attraction in fed females, while it has no effect in males. Upregulation of sensitivity and behavioural responsiveness to cVA in fed females is paralleled by a strong increase in receptivity to male courtship. Functional imaging of the antennal lobe (AL), the olfactory centre in the insect brain, shows that olfactory input to DA1 and VM2 glomeruli is also modulated by starvation. Knocking down insulin receptors in neurons converging onto the DA1 glomerulus suggests that insulin-signalling partly controls pheromone perception in the AL, and adjusts cVA attraction according to nutritional state and sexual receptivity in Drosophila females" |
| Keywords: | Acetates/chemistry/*pharmacology Acetic Acid/pharmacology Animals Brain/metabolism/pathology Drosophila Proteins/antagonists & inhibitors/genetics/metabolism Drosophila melanogaster/*physiology Feeding Behavior/*drug effects Female Insulin/metabolism Male; |
| Notes: | "MedlineLebreton, Sebastien Trona, Federica Borrero-Echeverry, Felipe Bilz, Florian Grabe, Veit Becher, Paul G Carlsson, Mikael A Nassel, Dick R Hansson, Bill S Sachse, Silke Witzgall, Peter eng Research Support, Non-U.S. Gov't England 2015/08/11 Sci Rep. 2015 Aug 10; 5:13132. doi: 10.1038/srep13132" |
