| Title: | Brain Injury Alters Volatile Metabolome |
| Author(s): | Kimball BA; Cohen AS; Gordon AR; Opiekun M; Martin T; Elkind J; Lundstrom JN; Beauchamp GK; |
| Address: | "USDA-APHIS-WS-NWRC, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA, bruce.a.kimball@aphis.usda.gov. Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA, Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA. Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA and Department of Clinical Neuroscience, Karolinska Institutet, Nobels vag 9, 17177 Stockholm, Sweden. Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA and. Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA" |
| ISSN/ISBN: | 1464-3553 (Electronic) 0379-864X (Print) 0379-864X (Linking) |
| Abstract: | "Chemical signals arising from body secretions and excretions communicate information about health status as have been reported in a range of animal models of disease. A potential common pathway for diseases to alter chemical signals is via activation of immune function-which is known to be intimately involved in modulation of chemical signals in several species. Based on our prior findings that both immunization and inflammation alter volatile body odors, we hypothesized that injury accompanied by inflammation might correspondingly modify the volatile metabolome to create a signature endophenotype. In particular, we investigated alteration of the volatile metabolome as a result of traumatic brain injury. Here, we demonstrate that mice could be trained in a behavioral assay to discriminate mouse models subjected to lateral fluid percussion injury from appropriate surgical sham controls on the basis of volatile urinary metabolites. Chemical analyses of the urine samples similarly demonstrated that brain injury altered urine volatile profiles. Behavioral and chemical analyses further indicated that alteration of the volatile metabolome induced by brain injury and alteration resulting from lipopolysaccharide-associated inflammation were not synonymous. Monitoring of alterations in the volatile metabolome may be a useful tool for rapid brain trauma diagnosis and for monitoring recovery" |
| Keywords: | "Animals Behavior, Animal/drug effects Brain Injuries/metabolism/*pathology Discriminant Analysis Disease Models, Animal Inflammation/etiology Lipopolysaccharides/toxicity Male Mice Mice, Inbred C57BL Volatile Organic Compounds/*metabolism/pharmacology/uri;" |
| Notes: | "MedlineKimball, Bruce A Cohen, Akiva S Gordon, Amy R Opiekun, Maryanne Martin, Talia Elkind, Jaclynn Lundstrom, Johan N Beauchamp, Gary K eng R01 NS069629/NS/NINDS NIH HHS/ R37 HD059288/HD/NICHD NIH HHS/ S10 OD018125/OD/NIH HHS/ Research Support, N.I.H., Extramural England 2016/03/02 Chem Senses. 2016 Jun; 41(5):407-14. doi: 10.1093/chemse/bjw014. Epub 2016 Feb 28" |
