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Molecules

Title:		In Vitro and In Vivo Human Body Odor Analysis Method Using GO:PANI/ZNRs/ZIF-8 Adsorbent Followed by GC/MS
Author(s):		Kim S; Bae S;
Address:		"Department of Chemistry, Seoul Women's University, 621 Hwarang-ro, Nowon-gu, Seoul 01797, Korea"
Journal Title:		Molecules
Year:		2022
Volume:		20220727
Issue:		15
Page Number:		-
DOI:		10.3390/molecules27154795
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Among various volatile organic compounds (VOCs) emitted from human skin, trans-2-nonenal, benzothiazole, hexyl salicylate, alpha-hexyl cinnamaldehyde, and isopropyl palmitate are key indicators associated with the degrees of aging. In our study, extraction and determination methods of human body odor are newly developed using headspace-in needle microextraction (HS-INME). The adsorbent was synthesized with graphene oxide:polyaniline/zinc nanorods/zeolitic imidazolate framework-8 (GO:PANI/ZNRs/ZIF-8). Then, a wire coated with the adsorbent was placed into the adsorption kit to be directly exposed to human skin as in vivo sampling and inserted into the needle so that it was able to be desorbed at the GC injector. The adsorption kit was made in-house with a 3D printer. For the in vitro method, the wire coated with the adsorbent was inserted into the needle and exposed to the headspace of the vial. When a cotton T-shirt containing body odor was transferred to a vial, the headspace of the vial was saturated with body odor VOCs. After volatile organic compounds were adsorbed in the dynamic mode, the needle was transferred to the injector for analysis of the volatile organic compounds by gas chromatography/mass spectrometry (GC/MS). The conditions of adsorbent fabrication and extraction for body odor compounds were optimized by response surface methodology (RSM). In conclusion, it was able to synthesize GO:PANI/ZNRs/ZIF-8 at the optimal condition and applicable to both in vivo and in vitro methods for body odor VOCs analysis"
Keywords:		Body Odor Gas Chromatography-Mass Spectrometry/methods Humans Odorants/analysis Solid Phase Microextraction/methods *Volatile Organic Compounds/analysis GO:PANI/ZNRs/ZIF-8 headspace-in needle microextraction human body odor needle-based adsorbent response;
Notes:		"MedlineKim, Sehyun Bae, Sunyoung eng 2020R1A2C1014112/National Research Foundation of Korea/ 2022-0081/seoul women's university/ Switzerland 2022/08/13 Molecules. 2022 Jul 27; 27(15):4795. doi: 10.3390/molecules27154795"