| Title: | Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) |
| Author(s): | Andrade PM; Melo DC; Alcoba AET; Ferreira Junior WG; Pagotti MC; Magalhaes LG; Santos T; Crotti AEM; Alves CCF; Miranda MLD; |
| Address: | "Instituto Federal de Educacao, Ciencia e Tecnologia do Sul de Minas Gerais, Campus Pouso Alegre, Av. Maria da Conceicao Santos, 900, Parque Real, 37550-000 Pouso Alegre, MG, Brazil. Instituto Federal de Educacao, Ciencia e Tecnologia do Sul de Minas Gerais, Campus Machado, Rod. Machado-Paraguacu, s/n, Santo Antonio, 37750-000 Machado, MG, Brazil. Centro de Pesquisa em Ciencias Exatas e Tecnologia, Universidade de Franca, Av. Dr. Armando de Salles Oliveira, 201, Parque Universitario, 14404-600 Franca, SP, Brazil. Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av. Bandeirantes, 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil. Instituto Federal de Educacao, Ciencia e Tecnologia Goiano, Campus Rio Verde, Av. Sul Goiana, s/n, Zona Rural, 75901-970 Rio Verde, GO, Brazil. Instituto Federal de Educacao, Ciencia e Tecnologia do Triangulo Mineiro, Campus Uberlandia Centro, Rua Blanche Galassi, 150, Morada da Colina, 38411-104 Uberlandia, MG, Brazil" |
| DOI: | 10.1590/0001-3765201820170332 |
| ISSN/ISBN: | 1678-2690 (Electronic) 0001-3765 (Linking) |
| Abstract: | "Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which affects around two million people worldwide. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Medicinal and aromatic plants constitute a major source of natural organic compounds. In this study, the leaf essential oil of Cryptocarya aschersoniana was obtained by hydrodistillation in a Clevenger-type apparatus, and the chemical composition was analyzed by GC-MS and GC-FID. The essential oil of these species was predominantly constituted by monoterpene hydrocarbons (48.8%). Limonene (42.3%), linalool (9.7%) and nerolidol (8.6%) were the main constituents in the oil of C. aschersoniana. The in vitro activity of the oil was evaluated against the promastigote forms of Leishmania amazonensis, the causative agent of cutaneous leishmaniasis in humans. The essential oil of C. aschersoniana showed high activity against L. amazonensis promastigote forms (IC50 = 4.46 microg/mL), however, it also demonstrated a relatively high cytotoxicity on mouse peritoneal macrophages (CC50 = 7.71 microg/mL). This is the first report of the chemical composition and the leishmanicidal and cytotoxic activities of the leaf essential oil of C. aschersoniana" |
| Keywords: | "Animals Antiprotozoal Agents/chemistry/isolation & purification/*pharmacology Cryptocarya/*chemistry/classification Gas Chromatography-Mass Spectrometry Inhibitory Concentration 50 Leishmania/*drug effects Macrophages, Peritoneal/*drug effects Mice Mice, ;" |
| Notes: | "MedlineAndrade, Priscila M DE Melo, Daiana C DE Alcoba, Ana Elisa T Ferreira Junior, Walnir G Pagotti, Mariana C Magalhaes, Lizandra G Santos, Taina C L Dos Crotti, Antonio E M Alves, Cassia C F Miranda, Mayker L D eng Brazil 2018/10/12 An Acad Bras Cienc. 2018 Jul-Sep; 90(3):2671-2678. doi: 10.1590/0001-3765201820170332" |
