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Peptides

Title:		Inhibition of PK/PBAN-mediated functions in insects: discovery of selective and non-selective inhibitors
Author(s):		Altstein M; Ben-Aziz O; Zeltser I; Bhargava K; Davidovitch M; Strey A; Pryor N; Nachman RJ;
Address:		"Department of Entomology, The Volcani Center, Bet Dagan 50250, Israel. vinnie2@agri.gov.il"
Journal Title:		Peptides
Year:		2007
Volume:		20070104
Issue:		3
Page Number:		574 - 584
DOI:		10.1016/j.peptides.2006.11.018
ISSN/ISBN:		0196-9781 (Print) 0196-9781 (Linking)
Abstract:		"The antagonistic properties of a few linear and backbone cyclic (BBC) conformationally constraint peptide libraries and their analogs, were tested for the ability to inhibit pyrokinin/pheromone biosynthesis activating neuropeptide (PK/PBAN) mediated functions: sex pheromone biosynthesis in Heliothis peltigera female moths, cuticular melanization in Spodoptera littoralis larvae, pupariation in the fleshfly Neobellieria bullata and hindgut contraction in Leucophaea maderae, elicited by exogenously injected PBAN, pheromonotropin (PT), leucopyrokinin (LPK), myotropin (MT) or by the endogenous peptides. The data revealed differential inhibitory patterns within the same assay with different elicitors (in both the pheromonotropic and melanotropic assays) and among the different functions and disclosed selective antagonists, hinting at the possibility that the receptors that mediate those functions may differ from one another structurally"
Keywords:		Amino Acid Sequence Animals Female In Vitro Techniques Insecta/*drug effects/genetics/growth & development/*metabolism Male Melanins/biosynthesis Muscle Contraction/drug effects Neuropeptides/*antagonists & inhibitors/genetics/metabolism Oligopeptides/gen;
Notes:		"MedlineAltstein, Miriam Ben-Aziz, Orna Zeltser, Irina Bhargava, Kalpana Davidovitch, Michael Strey, Allison Pryor, Nan Nachman, Ronald J eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2007/01/09 Peptides. 2007 Mar; 28(3):574-84. doi: 10.1016/j.peptides.2006.11.018. Epub 2007 Jan 4"