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Crit Rev Food Sci Nutr

Title:		"Allium vegetables: Traditional uses, phytoconstituents, and beneficial effects in inflammation and cancer"
Author(s):		Alam A; Al Arif Jahan A; Bari MS; Khandokar L; Mahmud MH; Junaid M; Chowdhury MS; Khan MF; Seidel V; Haque MA;
Address:		"Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh. Department of Chemistry, Purdue University, West Lafayette, Indiana, USA. Department of Pharmacy, East West University, Dhaka, Bangladesh. Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"
Journal Title:		Crit Rev Food Sci Nutr
Year:		2023
Volume:		20220216
Issue:		23
Page Number:		6580 - 6614
DOI:		10.1080/10408398.2022.2036094
ISSN/ISBN:		1549-7852 (Electronic) 1040-8398 (Linking)
Abstract:		"The genus Allium comprises of at least 918 species; the majority grown for dietary and medicinal purposes. This review describes the traditional uses, phytoconstituents, anti-inflammatory and anticancer activity, and safety profile of six main species, namely Allium sativum L. (garlic), Allium cepa L. (onions), Allium ampeloprasum L. (leek), Allium fistulosum L. (scallion), Allium schoenoprasum L. (chives) and Allium tuberosum Rottler (garlic chives). These species contain at least 260 phytoconstituents; mainly volatile compounds-including 63 organosulfur molecules-, saponins, flavonoids, anthocyanins, phenolic compounds, amino acids, organic acids, fatty acids, steroids, vitamins and nucleosides. They have prominent in vitro anti-inflammatory activity, and in vivo replications of such results have been achieved for all except for A. schoenoprasum. They also exert cytotoxicity against different cancer cell lines. Several anticancer phytoconstituents have been characterized from all except for A. fistulosum. Organosulfur constituents, saponins and flavonoid glycosides have demonstrated anti-inflammatory and anticancer activity. Extensive work has been conducted mainly on the anti-inflammatory and anticancer activity of A. sativum and A. cepa. The presence of anti-inflammatory and anticancer constituents in these two species suggests that similar bioactive constituents could be found in other species. This provides future avenues for identifying new Allium-derived anti-inflammatory and anticancer agents"
Keywords:		Humans Vegetables Anthocyanins/metabolism Onions/chemistry *Garlic/chemistry *Neoplasms/drug therapy Antioxidants/analysis Inflammation/drug therapy Flavonoids/pharmacology/metabolism Allium vegetables anti-inflammatory activity anticancer activity ethnop;
Notes:		"MedlineAlam, Ashraful Al Arif Jahan, Abdullah Bari, Md Sazzadul Khandokar, Labony Mahmud, Md Hasan Junaid, Muhammed Chowdhury, Mohammed Salahuddin Khan, Mohammad Forhad Seidel, Veronique Haque, Md Areeful eng Review 2022/02/17 Crit Rev Food Sci Nutr. 2023; 63(23):6580-6614. doi: 10.1080/10408398.2022.2036094. Epub 2022 Feb 16"