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Gastrointest Endosc

Title:		Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study
Author(s):		Bhatt A; Parsi MA; Stevens T; Gabbard S; Kumaravel A; Jang S; Grove D; Lopez R; Murthy S; Vargo JJ; Dweik R;
Address:		"Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA. Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA. Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio, USA"
Journal Title:		Gastrointest Endosc
Year:		2016
Volume:		20151202
Issue:		4
Page Number:		597 - 603
DOI:		10.1016/j.gie.2015.11.031
ISSN/ISBN:		1097-6779 (Electronic) 0016-5107 (Linking)
Abstract:		"BACKGROUND AND AIMS: A noninvasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for the diagnosis of EAC has not been previously studied. METHODS: Plasma samples were collected from subjects with EAC and GERD before endoscopy. Twenty-two preselected VOCs were analyzed with selected ion flow tube mass spectrometry. RESULTS: The headspaces from 39 plasma samples (20 EAC, 19 GERD) were analyzed. The levels of 9 VOCs (acetonitrile, acrylonitrile, carbon disulfide, isoprene, 1-heptene, 3-methylhexane, [E]-2-nonene, hydrogen sulfide, and triethylamine) were significantly altered in EAC patients compared with GERD patients. A multivariable logistic regression analysis was performed to build a model for the prediction of EAC. The model identified patients with EAC with an area under the curve of 0.83 (95% confidence interval, 0.67-0.98). CONCLUSIONS: Plasma VOCs may be useful in diagnosing EAC. Larger studies are needed to confirm our pilot study observations"
Keywords:		"Acetonitriles/blood Acrylonitrile/blood Adenocarcinoma/*blood/diagnosis Adult Aged Area Under Curve Butadienes/blood Carbon Disulfide/blood Case-Control Studies Cross-Sectional Studies Endoscopy, Digestive System Esophageal Neoplasms/*blood/diagnosis Ethy;"
Notes:		"MedlineBhatt, Amit Parsi, Mansour A Stevens, Tyler Gabbard, Scott Kumaravel, Arthi Jang, Sunguk Grove, David Lopez, Rocio Murthy, Sudish Vargo, John J Dweik, Raed eng 2015/12/10 Gastrointest Endosc. 2016 Oct; 84(4):597-603. doi: 10.1016/j.gie.2015.11.031. Epub 2015 Dec 2"