| Title: | Comparison of True and Smoothed Puff Profile Replication on Smoking Behavior and Mainstream Smoke Emissions |
| Author(s): | Brinkman MC; Kim H; Chuang JC; Kroeger RR; Deojay D; Clark PI; Gordon SM; |
| Address: | "Tobacco Exposure Research Laboratory, Battelle Memorial Institute , 505 King Avenue, Columbus, Ohio 43201, United States. University of Maryland , College Park, Maryland 20742, United States" |
| ISSN/ISBN: | 1520-5010 (Electronic) 0893-228X (Print) 0893-228X (Linking) |
| Abstract: | "To estimate exposures to smokers from cigarettes, smoking topography is typically measured and programmed into a smoking machine to mimic human smoking, and the resulting smoke emissions are tested for relative levels of harmful constituents. However, using only the summary puff data--with a fixed puff frequency, volume, and duration--may underestimate or overestimate actual exposure to smoke toxins. In this laboratory study, we used a topography-driven smoking machine that faithfully reproduces a human smoking session and individual human topography data (n = 24) collected during previous clinical research to investigate if replicating the true puff profile (TP) versus the mathematically derived smoothed puff profile (SM) resulted in differences in particle size distributions and selected toxic/carcinogenic organic compounds from mainstream smoke emissions. Particle size distributions were measured using an electrical low pressure impactor, the masses of the size-fractionated fine and ultrafine particles were determined gravimetrically, and the collected particulate was analyzed for selected particle-bound, semivolatile compounds. Volatile compounds were measured in real time using a proton transfer reaction-mass spectrometer. By and large, TP levels for the fine and ultrafine particulate masses as well as particle-bound organic compounds were slightly lower than the SM concentrations. The volatile compounds, by contrast, showed no clear trend. Differences in emissions due to the use of the TP and SM profiles are generally not large enough to warrant abandoning the procedures used to generate the simpler smoothed profile in favor of the true profile" |
| Keywords: | Carcinogens/*analysis/*metabolism Environmental Exposure/analysis Humans Particle Size Smoke/*analysis Smoking/*metabolism *Tobacco Tobacco Smoke Pollution/analysis Volatile Organic Compounds/analysis/metabolism; |
| Notes: | "MedlineBrinkman, Marielle C Kim, Hyoshin Chuang, Jane C Kroeger, Robyn R Deojay, Dawn Clark, Pamela I Gordon, Sydney M eng R01 CA129511/CA/NCI NIH HHS/ R21 CA133893/CA/NCI NIH HHS/ R01CA129511/CA/NCI NIH HHS/ R21CA133893/CA/NCI NIH HHS/ Comparative Study Research Support, N.I.H., Extramural 2014/12/24 Chem Res Toxicol. 2015 Feb 16; 28(2):182-90. doi: 10.1021/tx500318h. Epub 2015 Jan 13" |
