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Int J Mol Sci

Title:		A Molecular Basis for Reciprocal Regulation between Pheromones and Hormones in Response to Dietary Cues in C. elegans
Author(s):		Park S; Park JY; Paik YK;
Address:		"Yonsei Proteome Research Center, Yonsei University, Seoul 03722, Korea"
Journal Title:		Int J Mol Sci
Year:		2020
Volume:		20200329
Issue:		7
Page Number:		-
DOI:		10.3390/ijms21072366
ISSN/ISBN:		1422-0067 (Electronic) 1422-0067 (Linking)
Abstract:		"Under stressful conditions, the early larvae of C. elegans enter dauer diapause, a non-aging period, driven by the seemingly opposite influence of ascaroside pheromones (ASCRs) and steroid hormone dafachronic acids (DAs). However, the molecular basis of how these small molecules engage in competitive crosstalk in coordination with insulin/IGF-1 signaling (IIS) remains elusive. Here we report a novel transcriptional regulatory pathway that seems to operate between the ASCR and DA biosynthesis under ad libitum (AL) feeding conditions or bacterial deprivation (BD). Although expression of the ASCR and DA biosynthetic genes reciprocally inhibit each other, ironically and interestingly, such dietary cue-mediated modulation requires the presence of the competitors. Under BD, induction of ASCR biosynthetic gene expression required DA, while ASCR suppresses the expression of the DA biosynthetic gene daf-36. The negative regulation of DA by ASCR was IIS-dependent, whereas daf-36 regulation appeared to be independent of IIS. These observations suggest that the presence of ASCR determines the IIS-dependency of DA gene expression regardless of dietary conditions. Thus, our work defines a molecular basis for a novel reciprocal gene regulation of pheromones and hormones to cope with stressful conditions during development and aging"
Keywords:		"*Animal Nutritional Physiological Phenomena Animals Caenorhabditis elegans/*physiology Caenorhabditis elegans Proteins/genetics/metabolism Cholestenes/metabolism *Cues Gene Expression Regulation Hormones/*genetics/*metabolism Models, Biological Pheromones;"
Notes:		"MedlinePark, Saeram Park, Jun Young Paik, Young-Ki eng P40 OD010440/OD/NIH HHS/ 2017R1A2B3003200/National Research Foundation of Korea/ Switzerland 2020/04/03 Int J Mol Sci. 2020 Mar 29; 21(7):2366. doi: 10.3390/ijms21072366"