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Environ Res

Title:		Cigarette smoking is associated with acrylamide exposure among the U.S. population: NHANES 2011-2016
Author(s):		Kenwood BM; Zhu W; Zhang L; Bhandari D; Blount BC;
Address:		"Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA. Electronic address: mnv9@cdc.gov. Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA"
Journal Title:		Environ Res
Year:		2022
Volume:		20220122
Issue:
Page Number:		112774 -
DOI:		10.1016/j.envres.2022.112774
ISSN/ISBN:		1096-0953 (Electronic) 0013-9351 (Linking)
Abstract:		"2-carbamoylethyl mercapturic acid (2CaEMA, N-Acetyl-S-carbamoylethyl-L-cysteine) is a urinary metabolite and exposure biomarker of acrylamide, which is a harmful volatile organic compound found in cigarette smoke and in some foods. The goal of this study was to determine the association between cigarette smoking and urinary 2CaEMA concentrations among the U.S. population while considering potential dietary sources of acrylamide intake and demographics. We measured 2CaEMA concentrations in urine specimens collected during the National Health and Nutrition Examination Survey 2011-2012, 2013-2014, and 2015-2016 cycles from eligible participants 18 years and older (n = 5443) using liquid chromatography/tandem mass spectrometry. We developed multiple regression models with urinary 2CaEMA concentrations as the dependent variable and sex, age, race/Hispanic origin, reported primary sources of dietary acrylamide intake, and cigarette smoke exposure as independent variables. This study demonstrates that cigarette smoking is strongly associated with urinary 2CaEMA, suggests that cigarette smoking is likely a primary source of acrylamide exposure, and provides a baseline measure for 2CaEMA in the U.S. population"
Keywords:		"Acetylcysteine Acrylamide Chromatography, Liquid *Cigarette Smoking Humans Nutrition Surveys 2-Carbamoylethyl mercapturic acid (2CaEMA) Aama Gama The national health and nutrition examination survey (NHANES) Tobacco smoke;"
Notes:		"MedlineKenwood, Brandon M Zhu, Wanzhe Zhang, Luyu Bhandari, Deepak Blount, Benjamin C eng Netherlands 2022/01/26 Environ Res. 2022 Jun; 209:112774. doi: 10.1016/j.envres.2022.112774. Epub 2022 Jan 22"