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Langmuir

Title:		Formation of organic nanoparticles by electrospinning of volatile microemulsions
Author(s):		Dvores MP; Marom G; Magdassi S;
Address:		"Casali Institute of Applied Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel"
Journal Title:		Langmuir
Year:		2012
Volume:		20120419
Issue:		17
Page Number:		6978 - 6984
DOI:		10.1021/la204741f
ISSN/ISBN:		1520-5827 (Electronic) 0743-7463 (Linking)
Abstract:		"This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which a model material, propylparaben, has been dissolved within the volatile dispersed phase in the presence of a high-molecular-weight polymer. The approach is based on nanoscale confinement to the dispersed phase of an oil-in-water microemulsion with a volatile oil phase, in which the poorly water-soluble materials are dissolved. Thus, when the thermodynamically stable oil-in-water microemulsion is combined with the rapid evaporation of solvent inherent in the electrospinning process, the droplets are converted into organic nanoparticles embedded within a polymeric nanofiber. In addition to possessing process simplicity, this method exhibits a very high percentage of nanoparticle loading with desirable active material properties. Specifically, the diameter of the nanofibers is in the range of 60-185 nm, and propylparaben exists within the nanofiber as nanocrystals of 30-120 nm. These dimensions suggest that the nanofiber-nanocrystal composites could serve as a delivery system for water-insoluble materials"
Keywords:		Electric Conductivity Emulsions Nanofibers/chemistry Nanoparticles/*chemistry Nanotechnology/*methods Parabens/*chemistry Particle Size Polyethylene Glycols/chemistry Solubility Volatilization Water/chemistry X-Ray Diffraction;
Notes:		"MedlineDvores, Michelle P Marom, Gad Magdassi, Shlomo eng 2012/03/29 Langmuir. 2012 May 1; 28(17):6978-84. doi: 10.1021/la204741f. Epub 2012 Apr 19"