| Title: | Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil |
| Author(s): | Erik I; Bozdal G; Sener SO; Korkmaz B; Karaoglu SA; Terzioglu S; Yayli N; |
| Address: | "Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey. Department of Botany, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey. Department of Biology, Faculty of Science, Recep Tayyip Erdogan University, Rize, Turkey. Department of Forest Botany, Faculty of Forestry, Karadeniz Technical University, Trabzon, Turkey" |
| ISSN/ISBN: | 1300-0527 (Print) 1303-6130 (Electronic) 1300-0527 (Linking) |
| Abstract: | "The essential oil (EO) of Cota tinctoria var. tinctoria was analyzed using GC-FID / MS. A total of 51 compounds were determined from this taxon, accounting for 99.79% in hydrodistillation. Monoterpenes were the primary chemical class for the volatile organic compounds in the EO (36.1%, 13 compounds). Borneol (18.1%), camphor (14.9%), and beta-pinene (11.3%) were the major components in the EO of C. tinctoria var. tinctoria. The antimicrobial activities of EO and n-hexane, acetonitrile, methanol, and water solvent extracts of the taxon were screened in vitro against ten microorganisms. The EO yielded the best activity (15 mm, 372.5 MIC, 59600 mug/muL) against Mycobacterium smegmatis. The acetonitrile extract was the most active against the Staphylococcus aureus and Bacillus cereus with 274 mug/mL MIC value. IC(50) values for the lipase enzyme inhibitory activity of EO and solvent extracts (n-hexane, acetonitrile, methanol, and water) were found to be 59.80 +/- 4.3285 mug/mL 68.28 +/- 3.1215 mug/mL, 52.60 +/- 3.7526 mug/mL, 48.73 +/- 2.8265 mug/mL, and 99.50 +/- 5.5678 mug/mL, respectively" |
| Keywords: | Antimicrobial Cota tinctoria var.tinctoria Gc-fid/ms lipase inhibition volatile compounds; |
| Notes: | "PubMed-not-MEDLINEErik, Ishak Bozdal, Gozde Sener, Sila Ozlem Korkmaz, Busra Karaoglu, Sengul Alpay Terzioglu, Salih Yayli, Nurettin eng Turkey 2022/04/14 Turk J Chem. 2022 Apr 14; 46(4):1234-1244. doi: 10.55730/1300-0527.3430. eCollection 2022" |
