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Trends Genet

Title:		"V2R gene families degenerated in primates, dog and cow, but expanded in opossum"
Author(s):		Young JM; Trask BJ;
Address:		"Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3-168, Seattle, WA 98109 USA. jayoung@fhcrc.org"
Journal Title:		Trends Genet
Year:		2007
Volume:		20070326
Issue:		5
Page Number:		212 - 215
DOI:		10.1016/j.tig.2007.03.004
ISSN/ISBN:		0168-9525 (Print) 0168-9525 (Linking)
Abstract:		"The V2R genes are expressed in the mammalian vomeronasal organ, and their products are involved in detecting pheromones. Here, we describe the evolution of the V2R gene family. We have found that the human, chimpanzee, macaque, cow and dog V2R gene families have completely degenerated. Each now contains 9-20 pseudogenes but no intact V2R genes. By contrast, opossum has approximately 90 intact V2R genes that mostly arose by duplication after opossum and rodent lineages diverged. One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined"
Keywords:		"Animals Cattle Dogs Evolution, Molecular Gene Duplication Hominidae/*genetics Humans Mammals/*genetics *Multigene Family Opossums/*genetics Primates/*genetics Species Specificity *Vomeronasal Organ;"
Notes:		"MedlineYoung, Janet M Trask, Barbara J eng R01 DC004209/DC/NIDCD NIH HHS/ R01 CA092167-03/CA/NCI NIH HHS/ R01 CA092167/CA/NCI NIH HHS/ DC004209/DC/NIDCD NIH HHS/ CA092167/CA/NCI NIH HHS/ R01 DC004209-09/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural England 2007/03/27 Trends Genet. 2007 May; 23(5):212-5. doi: 10.1016/j.tig.2007.03.004. Epub 2007 Mar 26"